Phenotypes associated with this allele

• Allele Symbol: Tg(tetO/CMV-CD200)1Rmgo
• Allele Name: transgene insertion 1, Reg M Gorczynski
• Allele ID: MGI:3804805
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cd200r1^tm1.1Rmgo/Cd200r1^tm1.1Rmgo Tg(tetO/CMV-CD200)1Rmgo/Tg(tetO/CMV-CD200)1Rmgo	involves: C57BL/6	MGI:3804820
tg2	Tg(tetO/CMV-CD200)1Rmgo/Tg(tetO/CMV-CD200)1Rmgo	involves: C57BL/6	MGI:3804818

Genotype
MGI:3804820

cx1

• Allelic Composition: Cd200r1^tm1.1Rmgo/Cd200r1^tm1.1Rmgo; Tg(tetO/CMV-CD200)1Rmgo/Tg(tetO/CMV-CD200)1Rmgo
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal dendritic cell physiology ( J:134313 )

• bone marrow derived dendritic cells from mice given doxycycline for 2 weeks are polarized to induce antigen specific T regulatory cells in vitro

• 4 x 10⁶ dendritic cells isolated from mutant mice are able to significantly prolong allogenic skin graft survival when transferred to C57BL/6 hosts

• these tolerogenic dendritic cells no longer suppress skin graft rejection if host mice are injected with neutralizing antibodies to TGF-beta1 and IL-10 at the same time as receiving dendritic cells

Genotype
MGI:3804818

tg2

• Allelic Composition: Tg(tetO/CMV-CD200)1Rmgo/Tg(tetO/CMV-CD200)1Rmgo
• Genetic Background: involves: C57BL/6

immune system

abnormal dendritic cell physiology ( J:134313 )

• bone marrow derived dendritic cells from mice given doxycycline for 2 weeks are polarized to induce antigen specific T regulatory cells as measured by reduced lysis in a mixed lymphocyte culture