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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppme1tm1Crv
targeted mutation 1, Benjamin J Cravatt
MGI:3804708
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ppme1tm1Crv/Ppme1tm1Crv involves: 129S6/SvEvTac * C57BL/6J MGI:3804893


Genotype
MGI:3804893
hm1
Allelic
Composition		 Ppme1tm1Crv/Ppme1tm1Crv
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppme1tm1Crv mutation (1 available); any Ppme1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:138002 )
• animals do not commence normal breathing or suckling behaviour and die during first day after birth

behavior/neurological
abnormal suckling behavior ( J:138002 )
• animals do not commence normal suckling behaviour after birth

respiratory system
abnormal breathing pattern ( J:138002 )
• animals do not commence normal breathing after birth

homeostasis/metabolism
abnormal enzyme/coenzyme activity ( J:138002 )
• phosphoprotein phosphatase 2A catalytic subunit (Ppp2ca) is not demethylated in mutant mice
• phosphoprotein phosphatase 2A catalytic subunit (Ppp2ca) activity is severely diminished




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory