Phenotypes associated with this allele

• Allele Symbol: Laptm5^tm1Jow
• Allele Name: targeted mutation 1, Jiyang O-Wang
• Allele ID: MGI:3803960
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Laptm5^tm1Jow/Laptm5^tm1Jow	C57BL/6-Laptm5^tm1Jow	MGI:3805366

Genotype
MGI:3805366

hm1

• Allelic Composition: Laptm5^tm1Jow/Laptm5^tm1Jow
• Genetic Background: C57BL/6-Laptm5^tm1Jow

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:137841 )

N • despite alterations in T cell response, mice exhibit normal T and B cell development and maturation as well as normal B cell response

abnormal T cell activation ( J:137841 )

• in response to CD3 stimulation more T cells produce IFN-gamma

• however, the amount of IFN-gamma produced by each cell is normal

increased T cell proliferation ( J:137841 )

• in response to CD3 stimulation or following immunization with keyhole limpet hemocyanin (KLH), T cells undergo an increase in cell division compared to in similarly treated wild-type mice

• however, CD3 stimulated increases in proliferation are not attributed to increased IL-2 production

abnormal type IV hypersensitivity reaction ( J:137841 )

• following sensitization and re-exposure to bovine serum albumin, mice exhibit a prolonged delayed-type hypersensitivity response to antigen stimulation compared to wild-type mice

increased interleukin-2 secretion ( J:137841 )

• following immunization with keyhole limpet hemocyanin (KLH), T cells exhibit an increase in IL-2 production compared to similarly treated wild-type mice

hematopoietic system

abnormal T cell activation ( J:137841 )

• in response to CD3 stimulation more T cells produce IFN-gamma

• however, the amount of IFN-gamma produced by each cell is normal

increased T cell proliferation ( J:137841 )

• in response to CD3 stimulation or following immunization with keyhole limpet hemocyanin (KLH), T cells undergo an increase in cell division compared to in similarly treated wild-type mice

• however, CD3 stimulated increases in proliferation are not attributed to increased IL-2 production

cellular

increased T cell proliferation ( J:137841 )

• in response to CD3 stimulation or following immunization with keyhole limpet hemocyanin (KLH), T cells undergo an increase in cell division compared to in similarly treated wild-type mice

• however, CD3 stimulated increases in proliferation are not attributed to increased IL-2 production