Phenotypes associated with this allele

• Allele Symbol: Pgia9^DBA/2
• Allele Name: DBA/2
• Allele ID: MGI:3803908
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pgia9^DBA/2/Pgia9^DBA/2	C.D2-(D15Mit267-D15Mit41)	MGI:3803910
hm2	Pgia9^DBA/2/Pgia9^DBA/2	involves: BALB/c * DBA/2	MGI:3803930

Genotype
MGI:3803910

hm1

• Allelic Composition: Pgia9^DBA/2/Pgia9^DBA/2
• Genetic Background: C.D2-(D15Mit267-D15Mit41)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to induced arthritis ( J:137478 )

• 50% decrease in proteoglycan-induced arthritis incidence in females

• 10% decrease in proteoglycan-induced arthritis incidence in males

skeleton

decreased susceptibility to induced arthritis ( J:137478 )

• 50% decrease in proteoglycan-induced arthritis incidence in females

• 10% decrease in proteoglycan-induced arthritis incidence in males

Genotype
MGI:3803930

hm2

• Allelic Composition: Pgia9^DBA/2/Pgia9^DBA/2
• Genetic Background: involves: BALB/c * DBA/2

immune system

increased interleukin-6 secretion ( J:137478 )

• 2-fold increased IL-6 production during PGIA disease

increased tumor necrosis factor secretion ( J:137478 )

• 1.5- to 2-fold increased TNF-alpha production during PGIA disease

decreased susceptibility to induced arthritis ( J:137478 )

skeleton

decreased susceptibility to induced arthritis ( J:137478 )