Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1tm1.1Mam mutation
(0 available);
any
Bcl2l1 mutation
(104 available)
Bcl2l1tm1Dlo mutation
(0 available);
any
Bcl2l1 mutation
(104 available)
Tg(Aicda-cre)9Mbu mutation
(2 available)
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immune system
N |
• affinity maturation among NP-reactive B cells and germinal cell formation are normal
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• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the bone marrow compared to in similarly treated wild-type mice
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hematopoietic system
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• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the bone marrow compared to in similarly treated wild-type mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1tm1Dmta mutation
(0 available);
any
Mcl1 mutation
(33 available)
Tg(Aicda-cre)9Mbu mutation
(2 available)
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immune system
N |
• affinity maturation among NP-reactive B cells is normal
|
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• following immunization with NP-KLH
|
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• following immunization with NP-KLH
|
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• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the serum, spleen and bone marrow compared to in similarly treated wild-type mice
|
hematopoietic system
|
• following immunization with NP-KLH
|
|
• following immunization with NP-KLH
|
|
• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the serum, spleen and bone marrow compared to in similarly treated wild-type mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1tm1Dmta mutation
(0 available);
any
Mcl1 mutation
(33 available)
Tg(Aicda-cre)9Mbu mutation
(2 available)
|
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immune system
|
• following immunization with NP-KLH
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• following immunization with NP-KLH
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hematopoietic system
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• following immunization with NP-KLH
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• following immunization with NP-KLH
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1.2Mbu mutation
(0 available);
any
Tcf3 mutation
(39 available)
Tcf3tm1Mbu mutation
(1 available);
any
Tcf3 mutation
(39 available)
Tg(Aicda-cre)9Mbu mutation
(2 available)
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immune system
N |
• despite reduced B cell numbers, class switching and B cell proliferation following stimulation are normal following immunization
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• following immunization, the number of IgG2a- and IgG3-secreting cells is decreased compared to in wild-type mice
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• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal
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• at day 4 following immunization, the number of germinal cell B cells in the spleen is reduced and remains 7- to 4-fold lower at day 8 and 12 compared to in wild-type and heterozygous mice
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hematopoietic system
|
• following immunization, the number of IgG2a- and IgG3-secreting cells is decreased compared to in wild-type mice
|
|
• at day 4 following immunization, the number of germinal cell B cells in the spleen is reduced and remains 7- to 4-fold lower at day 8 and 12 compared to in wild-type and heterozygous mice
|
|
• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal
|