Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation
(0 available);
any
Igh-J mutation
(13 available)
Tg(IGH@yH1)2BJkbv mutation
(0 available)
Tg(IGK@yK1)9.2CJkbv mutation
(0 available)
|
|
|
hematopoietic system
|
|
• all B cells express human mu heavy chain immunoglobulin with most of the B cells also expressing human delta heavy chain
|
|
|
• late pro-B cell numbers are increased more than 2-fold compared to wild-type mice suggesting a less efficient V to DJ joining process
|
|
|
• the presence of the two transgenes rescues the block in B cell development that occurs in Igh-Jtm1Jkbv development
• mature B cells are found in the bone marrow, spleen and blood in numbers corresponding to 58%, 55%, and 30% of wild-type levels
|
|
|
• antibodies containing human mu heavy chain are found in the serum at a concentration of 350 micrograms per ml, a level over 500 fold higher than found in transgenic mice without the Igh-J targeted mutation
• the serum concentration of antibodies with human mu heavy chain is only 2- to 3- fold lower than the concentration of IgM found in humans
|
immune system
|
|
• all B cells express human mu heavy chain immunoglobulin with most of the B cells also expressing human delta heavy chain
|
|
|
• late pro-B cell numbers are increased more than 2-fold compared to wild-type mice suggesting a less efficient V to DJ joining process
|
|
|
• the presence of the two transgenes rescues the block in B cell development that occurs in Igh-Jtm1Jkbv development
• mature B cells are found in the bone marrow, spleen and blood in numbers corresponding to 58%, 55%, and 30% of wild-type levels
|
|
|
• antibodies containing human mu heavy chain are found in the serum at a concentration of 350 micrograms per ml, a level over 500 fold higher than found in transgenic mice without the Igh-J targeted mutation
• the serum concentration of antibodies with human mu heavy chain is only 2- to 3- fold lower than the concentration of IgM found in humans
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
|
|
|
immune system
|
|
• 0.8-3.9% of B cells express human mu heavy chain and 1.4-4.8% express human kappa chain
• 0.06% to 0.27% of B cells express both the human heavy and light chains
|
|
|
• human antibodies are found in the serum at 0.3 to 0.7 micrograms per ml
• antigen specific human antibodies are generated when mice are immunized with tetanus toxin fragment
|
hematopoietic system
|
|
• 0.8-3.9% of B cells express human mu heavy chain and 1.4-4.8% express human kappa chain
• 0.06% to 0.27% of B cells express both the human heavy and light chains
|
|
|
• human antibodies are found in the serum at 0.3 to 0.7 micrograms per ml
• antigen specific human antibodies are generated when mice are immunized with tetanus toxin fragment
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation
(0 available);
any
Igh-J mutation
(13 available)
Igkctm1Jkbv mutation
(0 available);
any
Igkc mutation
(9 available)
Tg(IGH@yH1)2BJkbv mutation
(0 available)
Tg(IGK@yK1)9.2CJkbv mutation
(0 available)
|
|
|
immune system
|
|
• 43% of B cells express human mu heavy chain and human kappa light chain
• 57% of B cells express human mu heavy chain and mouse lamda light chain
• no co-expression of human and mouse light chain is found
|
|
|
• the presence of the two transgenes overcomes the block in B cell development that occurs in Igh-Jtm1Jkbv Igk-Ctm1Jkbv double homozygotes
• mature B cells are found at a level 10% of that in wild-type mice
|
|
|
• human antibodies occur in the sera of mice at 10 micrograms per ml
• this concentration is several hundred fold higher than occurs in transgenic mice that do not have endogenous Ig heavy and light chains inactivated
|
hematopoietic system
|
|
• 43% of B cells express human mu heavy chain and human kappa light chain
• 57% of B cells express human mu heavy chain and mouse lamda light chain
• no co-expression of human and mouse light chain is found
|
|
|
• the presence of the two transgenes overcomes the block in B cell development that occurs in Igh-Jtm1Jkbv Igk-Ctm1Jkbv double homozygotes
• mature B cells are found at a level 10% of that in wild-type mice
|
|
|
• human antibodies occur in the sera of mice at 10 micrograms per ml
• this concentration is several hundred fold higher than occurs in transgenic mice that do not have endogenous Ig heavy and light chains inactivated
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkctm1Jkbv mutation
(0 available);
any
Igkc mutation
(9 available)
Tg(IGK@yK1)9.2CJkbv mutation
(0 available)
|
|
|
immune system
|
|
• immature B cells in circulation are at 70% of wild-type levels
|
|
|
• mature B cells are at 50-60% of wild-type levels in the spleen
• mature B cells in the blood and lymph nodes are 20-25% higher than in Igk-Ctm1Jkbv homozygotes
• mature B cells expressing human kappa light chain are found in similar numbers as B cells expressing murine lambda light chain
|
|
|
• there is a 2-fold accumulation of small pre- B cells in the bone marrow
|
|
|
• the concentration of antibodies containing murine lambda light chain are reduced to levels of 300 micrograms per ml compared to 580 micrograms per ml in Igk-Ctm1Jkbv homozygotes
• the concentration of antibodies containing human kappa light chain is 250 micrograms per ml in sera
|
hematopoietic system
|
|
• immature B cells in circulation are at 70% of wild-type levels
|
|
|
• mature B cells are at 50-60% of wild-type levels in the spleen
• mature B cells in the blood and lymph nodes are 20-25% higher than in Igk-Ctm1Jkbv homozygotes
• mature B cells expressing human kappa light chain are found in similar numbers as B cells expressing murine lambda light chain
|
|
|
• there is a 2-fold accumulation of small pre- B cells in the bone marrow
|
|
|
• the concentration of antibodies containing murine lambda light chain are reduced to levels of 300 micrograms per ml compared to 580 micrograms per ml in Igk-Ctm1Jkbv homozygotes
• the concentration of antibodies containing human kappa light chain is 250 micrograms per ml in sera
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkctm1Jkbv mutation
(0 available);
any
Igkc mutation
(9 available)
Tg(IGK@yK1)9.2CJkbv mutation
(0 available)
|
|
|
immune system
|
|
• B cells exclusively express lambda light chain and not kappa light chain
|
|
|
• immature B cells in circulation are at 70% of wild-type levels
|
|
|
• mature B cells are at 50-60% of wild-type levels in the spleen
• mature B cells in the blood and lymph nodes are 20-25% higher than in Igk-Ctm1Jkbv homozygotes
• mature B cells expressing human kappa light chain are twice as common as B cells expressing murine lambda light chain
|
|
|
• there is a 2-fold accumulation of small pre- B cells in the bone marrow
|
|
|
• the concentration of antibodies containing murine lambda light chain are reduced to levels of 300 micrograms per ml compared to 580 micrograms per ml in Igk-Ctm1Jkbv homozygotes
• the concentration of antibodies containing human kappa light chain is 720 micrograms per ml in sera
|
hematopoietic system
|
|
• B cells exclusively express lambda light chain and not kappa light chain
|
|
|
• immature B cells in circulation are at 70% of wild-type levels
|
|
|
• mature B cells are at 50-60% of wild-type levels in the spleen
• mature B cells in the blood and lymph nodes are 20-25% higher than in Igk-Ctm1Jkbv homozygotes
• mature B cells expressing human kappa light chain are twice as common as B cells expressing murine lambda light chain
|
|
|
• there is a 2-fold accumulation of small pre- B cells in the bone marrow
|
|
|
• the concentration of antibodies containing murine lambda light chain are reduced to levels of 300 micrograms per ml compared to 580 micrograms per ml in Igk-Ctm1Jkbv homozygotes
• the concentration of antibodies containing human kappa light chain is 720 micrograms per ml in sera
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation
(0 available);
any
Igh-J mutation
(13 available)
Igkctm1Jkbv mutation
(0 available);
any
Igkc mutation
(9 available)
Tg(IGH@yH1)2BJkbv mutation
(0 available)
Tg(IGK@yK1)9.2CJkbv mutation
(0 available)
|
|
|
immune system
|
|
• B cells develop inefficiently with a partial block occurring at the transition from pre- to pro- B cells
|
|
|
• B cells newly emerging from the bone marrow are at levels that are 10% of that in wild-type mice
|
|
|
• late pro B-cells accumulate at numbers 3- fold higher than in wild-type at the fraction C (CD43+ CD45+ HSAmed BP-1+) step
|
|
|
• the levels of circulating mature B cells are 10% of the numbers found in wild-type
• these B cells express human mu heavy chain
|
|
|
• pre-B cells numbers in the bone marrow are 30% of wild-type
|
hematopoietic system
|
|
• B cells develop inefficiently with a partial block occurring at the transition from pre- to pro- B cells
|
|
|
• B cells newly emerging from the bone marrow are at levels that are 10% of that in wild-type mice
|
|
|
• late pro B-cells accumulate at numbers 3- fold higher than in wild-type at the fraction C (CD43+ CD45+ HSAmed BP-1+) step
|
|
|
• the levels of circulating mature B cells are 10% of the numbers found in wild-type
• these B cells express human mu heavy chain
|
|
|
• pre-B cells numbers in the bone marrow are 30% of wild-type
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Jkbv mutation
(0 available);
any
Igh-J mutation
(13 available)
Igkctm1Jkbv mutation
(0 available);
any
Igkc mutation
(9 available)
Tg(IGH@yH1)2BJkbv mutation
(0 available)
Tg(IGK@yK1)9.2CJkbv mutation
(0 available)
|
|
|
immune system
|
|
• B cells develop inefficiently with a partial block occurring at the transition from pre- to pro- B cells
|
|
|
• B cells newly emerging from the bone marrow are at levels that are 30% of that in wild-type mice
|
|
|
• late pro B-cells accumulate at numbers 3- fold higher than in wild-type at the fraction C (CD43+ CD45+ HSAmed BP-1+) step
|
|
|
• the levels of circulating mature B cells are 10% of the numbers found in wild-type
• these B cells express human mu heavy chain
|
|
|
• pre-B cells numbers in the bone marrow are 70% of wild-type
|
|
|
• antibodies containing human mu and kappa immunoglobulin chains are found in the sera at levels of 150 and 120 micrograms per ml, respectively
|
hematopoietic system
|
|
• B cells develop inefficiently with a partial block occurring at the transition from pre- to pro- B cells
|
|
|
• B cells newly emerging from the bone marrow are at levels that are 30% of that in wild-type mice
|
|
|
• late pro B-cells accumulate at numbers 3- fold higher than in wild-type at the fraction C (CD43+ CD45+ HSAmed BP-1+) step
|
|
|
• the levels of circulating mature B cells are 10% of the numbers found in wild-type
• these B cells express human mu heavy chain
|
|
|
• pre-B cells numbers in the bone marrow are 70% of wild-type
|
|
|
• antibodies containing human mu and kappa immunoglobulin chains are found in the sera at levels of 150 and 120 micrograms per ml, respectively
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
|
|
|
immune system
|
|
• 9.3% of B cells express human kappa light chain
• 80% of the B cells that express human kappa light chain do not express endogenous murine light chains
|
|
|
• the V and J segments of the human transgene undergo recombination within B cells
|
|
|
• antibodies containing the human kappa light chain is found in the sera at 17.7 micrograms per ml
|
hematopoietic system
|
|
• 9.3% of B cells express human kappa light chain
• 80% of the B cells that express human kappa light chain do not express endogenous murine light chains
|
|
|
• the V and J segments of the human transgene undergo recombination within B cells
|
|
|
• antibodies containing the human kappa light chain is found in the sera at 17.7 micrograms per ml
|
Analysis Tools