Phenotypes associated with this allele

• Allele Symbol: Crem^tm1.1Endo
• Allele Name: targeted mutation 1.1, Shogo Endo
• Allele ID: MGI:3802585
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crem^tm1.1Endo/Crem^tm1.1Endo	C57BL/6-Crem^tm1.1Endo	MGI:3803752

Genotype
MGI:3803752

hm1

• Allelic Composition: Crem^tm1.1Endo/Crem^tm1.1Endo
• Genetic Background: C57BL/6-Crem^tm1.1Endo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:137666 )

N • despite altered conditioning memory, mice exhibit normal odor discrimination memory

abnormal contextual conditioning behavior ( J:137666 )

• mice display an increased freezing response 24 hours after conditioning compared to wild-type mice

• however, short-term conditioning is normal

abnormal cued conditioning behavior ( J:137666 )

• mice display an increased freezing response 24 hours after conditioning compared to wild-type mice

• however, short-term conditioning is normal

increased anxiety-related response ( J:137666 )

• latency to crossing into the light compartment is increased compared to for wild-type mice

abnormal kindling response ( J:137666 )

• mice develop more profound seizures sooner than similarly treated wild-type mice

• however, afterdischarge duration during kindling is normal

nervous system

abnormal kindling response ( J:137666 )

• mice develop more profound seizures sooner than similarly treated wild-type mice

• however, afterdischarge duration during kindling is normal