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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppargc1btm1Dpk
targeted mutation 1, Daniel P Kelly
MGI:3802518
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ppargc1atm2Brsp/Ppargc1atm2Brsp
Ppargc1btm1Dpk/Ppargc1btm1Dpk
Tg(Tyr-cre)1Lru/0 		involves: 129 * 129X1/SvJ * C57BL/6 MGI:6272349
cn2
 		Ppargc1atm1Dpk/Ppargc1atm1Dpk
Ppargc1btm1Dpk/Ppargc1btm1Dpk
Tg(Myh6-cre)2182Mds/0 		involves: 129X1/SvJ * FVB/N MGI:3802663


Genotype
MGI:6272349
cn1
Allelic
Composition		 Ppargc1atm2Brsp/Ppargc1atm2Brsp
Ppargc1btm1Dpk/Ppargc1btm1Dpk
Tg(Tyr-cre)1Lru/0
Genetic
Background		 involves: 129 * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargc1atm2Brsp mutation (0 available); any Ppargc1a mutation (47 available)
Ppargc1btm1Dpk mutation (1 available); any Ppargc1b mutation (59 available)
Tg(Tyr-cre)1Lru mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
pigmentation phenotype ( J:194191 )
N
• on a C57BL/6 background, mice show no change in baseline coat color relative to control mice




Genotype
MGI:3802663
cn2
Allelic
Composition		 Ppargc1atm1Dpk/Ppargc1atm1Dpk
Ppargc1btm1Dpk/Ppargc1btm1Dpk
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargc1atm1Dpk mutation (1 available); any Ppargc1a mutation (47 available)
Ppargc1btm1Dpk mutation (1 available); any Ppargc1b mutation (59 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:137598 )
• 67% of mice die within 24 hours of birth

cardiovascular system
abnormal myocardium layer morphology ( J:137598 )
• after birth, myocytes exhibit a reduction in mitochondrial number and size compared to in wild-type mice
decreased cardiac output ( J:137598 )
• similar to that found in Ppargc1atm1Dpk Ppargc1btm1.1Dpk homozygotes

muscle
abnormal myocardium layer morphology ( J:137598 )
• after birth, myocytes exhibit a reduction in mitochondrial number and size compared to in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory