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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wt1tm1(EGFP/cre)Wtp
targeted mutation 1, William T Pu
MGI:3801681
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Wt1tm1(EGFP/cre)Wtp/Wt1+
Zfpm2tm1Sho/Zfpm2tm2Sho 		involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd MGI:3851402
cn2
 		Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Wt1tm1(EGFP/cre)Wtp/Wt1+
Zfpm2tm1Sho/Zfpm2tm1Sho 		involves: 129S1/Sv * 129S4/SvJaeSor MGI:3851406
cn3
 		Dis3l2em2Jtm/Dis3l2em2Jtm
Wt1tm1(EGFP/cre)Wtp/Wt1+ 		involves: 129S4/SvJae * C57BL/6J MGI:6286059


Genotype
MGI:3851402
cn1
Allelic
Composition		 Wt1tm1(EGFP/cre)Wtp/Wt1+
Zfpm2tm1Sho/Zfpm2tm2Sho
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wt1tm1(EGFP/cre)Wtp mutation (1 available); any Wt1 mutation (34 available)
Zfpm2tm1Sho mutation (2 available); any Zfpm2 mutation (47 available)
Zfpm2tm2Sho mutation (1 available); any Zfpm2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:150452 )
• pups die in perinatal period

cardiovascular system
cardiovascular system phenotype ( J:150452 )
N
• coronary vascular development is not impaired
thin myocardium compact layer ( J:150452 )
• compact myocardium is thin
abnormal atrioventricular cushion morphology ( J:150452 )
• severe atrio-ventricular endocardial cushion defect is observed by E14.5

muscle
thin myocardium compact layer ( J:150452 )
• compact myocardium is thin




Genotype
MGI:3851406
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Wt1tm1(EGFP/cre)Wtp/Wt1+
Zfpm2tm1Sho/Zfpm2tm1Sho
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sho mutation (4 available); any Gt(ROSA)26Sor mutation (942 available)
Wt1tm1(EGFP/cre)Wtp mutation (1 available); any Wt1 mutation (34 available)
Zfpm2tm1Sho mutation (2 available); any Zfpm2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:150452 )
N
• mice show normal numbers of epicardium-derived cells (EPDCs) and epicardial epithelial-mesenchymal transition (EMT) occurs normally




Genotype
MGI:6286059
cn3
Allelic
Composition		 Dis3l2em2Jtm/Dis3l2em2Jtm
Wt1tm1(EGFP/cre)Wtp/Wt1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dis3l2em2Jtm mutation (1 available); any Dis3l2 mutation (56 available)
Wt1tm1(EGFP/cre)Wtp mutation (1 available); any Wt1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:272435 )
N
• mice exhibit normal kidney histology without evidence of malignancy up to at least 6 months of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory