About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wt1tm1(EGFP/cre)Wtp
targeted mutation 1, William T Pu
MGI:3801681
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Wt1tm1(EGFP/cre)Wtp/Wt1+
Zfpm2tm1Sho/Zfpm2tm2Sho 		involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd MGI:3851402
cn2
 		Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Wt1tm1(EGFP/cre)Wtp/Wt1+
Zfpm2tm1Sho/Zfpm2tm1Sho 		involves: 129S1/Sv * 129S4/SvJaeSor MGI:3851406
cn3
 		Dis3l2em2Jtm/Dis3l2em2Jtm
Wt1tm1(EGFP/cre)Wtp/Wt1+ 		involves: 129S4/SvJae * C57BL/6J MGI:6286059


Genotype
MGI:3851402
cn1
Allelic
Composition		 Wt1tm1(EGFP/cre)Wtp/Wt1+
Zfpm2tm1Sho/Zfpm2tm2Sho
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wt1tm1(EGFP/cre)Wtp mutation (1 available); any Wt1 mutation (34 available)
Zfpm2tm1Sho mutation (2 available); any Zfpm2 mutation (48 available)
Zfpm2tm2Sho mutation (1 available); any Zfpm2 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:150452 )
• pups die in perinatal period

cardiovascular system
cardiovascular system phenotype ( J:150452 )
N
• coronary vascular development is not impaired
thin myocardium compact layer ( J:150452 )
• compact myocardium is thin
abnormal atrioventricular cushion morphology ( J:150452 )
• severe atrio-ventricular endocardial cushion defect is observed by E14.5

muscle
thin myocardium compact layer ( J:150452 )
• compact myocardium is thin




Genotype
MGI:3851406
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Wt1tm1(EGFP/cre)Wtp/Wt1+
Zfpm2tm1Sho/Zfpm2tm1Sho
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sho mutation (4 available); any Gt(ROSA)26Sor mutation (1046 available)
Wt1tm1(EGFP/cre)Wtp mutation (1 available); any Wt1 mutation (34 available)
Zfpm2tm1Sho mutation (2 available); any Zfpm2 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:150452 )
N
• mice show normal numbers of epicardium-derived cells (EPDCs) and epicardial epithelial-mesenchymal transition (EMT) occurs normally




Genotype
MGI:6286059
cn3
Allelic
Composition		 Dis3l2em2Jtm/Dis3l2em2Jtm
Wt1tm1(EGFP/cre)Wtp/Wt1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dis3l2em2Jtm mutation (1 available); any Dis3l2 mutation (58 available)
Wt1tm1(EGFP/cre)Wtp mutation (1 available); any Wt1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:272435 )
N
• mice exhibit normal kidney histology without evidence of malignancy up to at least 6 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory