All Phenotypes Tbx18<tm1Sev> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tbx18^tm1Sev
targeted mutation 1, Sylvia Evans
MGI:3801039

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tbx18^tm1Sev/Tbx18^tm1.1Sev	involves: 129S4/SvJaeSor	MGI:5529161

Allelic Composition	Tbx18^tm1Sev/Tbx18^tm1.1Sev
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx18^tm1.1Sev mutation (0 available); any Tbx18 mutation (36 available)
Tbx18^tm1Sev mutation (1 available); any Tbx18 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality ( J:196480 )

• pups die soon after birth as result of skeletal abnormalities and respiratory distress

growth/size/body

decreased body length ( J:196480 )

• body length is shortened compared to wild-type at birth

integument

integument phenotype ( J:196480 )

N	• at E18.5, no differences in hair follicle morphology, total follicle numbers or follicle subtypes from all 3 waves relative to wild-type are observed

skeleton

abnormal skeleton morphology ( J:196480 )

respiratory system

respiratory distress ( J:196480 )

• observed at birth; contributes to postnatal death

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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