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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(TcrLCMV)318Sdz
transgene insertion 318, Birgit Ledermann
MGI:3801008
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Cd3gtm1.1Cage/Cd3gtm1.1Cage
Tg(TcrLCMV)318Sdz/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N MGI:4398877
cx2
Tg(Alb1-GP33/H2-Kb)1Hpi/0
Tg(Alb1-HBV)66Bri/0
Tg(TcrLCMV)318Sdz/0
involves: C57BL/6 * C57BL/10 * DBA/2 MGI:4838101
cx3
Tg(Alb1-GP33/H2-Kb)1Hpi/0
Tg(TcrLCMV)318Sdz/0
involves: C57BL/6 * DBA/2 MGI:4838099


Genotype
MGI:4398877
cx1
Allelic
Composition
Cd3gtm1.1Cage/Cd3gtm1.1Cage
Tg(TcrLCMV)318Sdz/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3gtm1.1Cage mutation (0 available); any Cd3g mutation (24 available)
Tg(TcrLCMV)318Sdz mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• adoptive transfer experiments demonstrate that reduced expansion of virus-specific CD8+ T cells is cell intrinsic and host independent

hematopoietic system




Genotype
MGI:4838101
cx2
Allelic
Composition
Tg(Alb1-GP33/H2-Kb)1Hpi/0
Tg(Alb1-HBV)66Bri/0
Tg(TcrLCMV)318Sdz/0
Genetic
Background
involves: C57BL/6 * C57BL/10 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Alb1-GP33/H2-Kb)1Hpi mutation (0 available)
Tg(Alb1-HBV)66Bri mutation (1 available)
Tg(TcrLCMV)318Sdz mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• only weak signs of hepatitis (less than 100 U/L) after LCMV infection

liver/biliary system
• only weak signs of hepatitis (less than 100 U/L) after LCMV infection




Genotype
MGI:4838099
cx3
Allelic
Composition
Tg(Alb1-GP33/H2-Kb)1Hpi/0
Tg(TcrLCMV)318Sdz/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• a reduction of CD8 single-positive (SP) thymocytes expressing the tg TCR
• the periphery exhibits an 8- to 10-fold decrease compared with that of single-tg TCR mice

immune system
• a reduction of CD8 single-positive (SP) thymocytes expressing the tg TCR
• the periphery exhibits an 8- to 10-fold decrease compared with that of single-tg TCR mice





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory