All Phenotypes Fmn1<tm1Awb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fmn1^tm1Awb
targeted mutation 1, Anthony Wynshaw-Boris
MGI:3800994

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fmn1^tm1Awb/Fmn1^tm1Awb	involves: 129S4/SvJae	MGI:3800997
hm2	Fmn1^tm1Awb/Fmn1^tm1Awb	involves: 129S4/SvJae * NIH Black Swiss	MGI:3800998
ht3	Fmn1^tm1Awb/Fmn1^{ld-Is(17;In2)1Gso}	involves: 101/Rl * 129S4/SvJae * C3H/Rl * NIH Black Swiss	MGI:3801003
ht4	Fmn1^tm1Awb/Fmn1^ld-TgBri137	involves: 129S4/SvJae * C57BL/6 * NIH Black Swiss * SJL	MGI:3801001

Allelic Composition	Fmn1^tm1Awb/Fmn1^tm1Awb
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmn1^tm1Awb mutation (0 available); any Fmn1 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:137209 )

• protrusion and retraction rates are increased and the persistence of protrusive activity and length of protrusions are decreased in MEFs

• plated MEFs show a significant reduction in focal adhesion area

Allelic Composition	Fmn1^tm1Awb/Fmn1^tm1Awb
Genetic Background	involves: 129S4/SvJae * NIH Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmn1^tm1Awb mutation (0 available); any Fmn1 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

absent kidney ( J:43337 )

• a small percentage of mice display bilateral renal agenesis

single kidney ( J:43337 )

• a small percentage of mice display unilateral renal agenesis

absent ureter ( J:43337 )

• in some cases of renal agenesis, the ureters on the ipsilateral side were absent

blind ureter ( J:43337 )

• in some cases of renal agenesis, blind-ended ureters originating from the bladder were present

limbs/digits/tail

limbs/digits/tail phenotype ( J:43337 )

N	• unlike mice homozygous for other Fmn1 alleles no limb deformities are detected

Allelic Composition	Fmn1^tm1Awb/Fmn1^{ld-Is(17;In2)1Gso}
Genetic Background	involves: 101/Rl * 129S4/SvJae * C3H/Rl * NIH Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmn1^{ld-Is(17;In2)1Gso} mutation (0 available); any Fmn1 mutation (75 available)
Fmn1^tm1Awb mutation (0 available); any Fmn1 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

polycystic kidney ( J:43337 )

• a small percentage of mice display bilateral multicystic dysplastic kidneys

limbs/digits/tail

limbs/digits/tail phenotype ( J:43337 )

N	• unlike mice homozygous for Fmn1^{ld-Is(17;In2)1Gso} no limb deformities are detected

growth/size/body

polycystic kidney ( J:43337 )

• a small percentage of mice display bilateral multicystic dysplastic kidneys

Allelic Composition	Fmn1^tm1Awb/Fmn1^ld-TgBri137
Genetic Background	involves: 129S4/SvJae * C57BL/6 * NIH Black Swiss * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmn1^ld-TgBri137 mutation (0 available); any Fmn1 mutation (75 available)
Fmn1^tm1Awb mutation (0 available); any Fmn1 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

single kidney ( J:43337 )

• a small percentage of mice display unilateral renal agenesis

limbs/digits/tail

limbs/digits/tail phenotype ( J:43337 )

N	• unlike mice homozygous for Fmn1^ld-TgBri137 no limb deformities are detected

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