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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map3k10tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3800582
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Map3k10tm1Lex/Map3k10tm1Lex 129S-Map3k10tm1Lex MGI:3801185
cx2
 		Map3k10tm1Lex/Map3k10tm1Lex
Map3k9tm1Lex/Map3k9tm1Lex 		either: 129S-Map3k10tm1Lex Map3k9tm1Lex or B6.129S-Map3k10tm1Lex Map3k9tm1Lex MGI:3801188


Genotype
MGI:3801185
hm1
Allelic
Composition		 Map3k10tm1Lex/Map3k10tm1Lex
Genetic
Background		 129S-Map3k10tm1Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k10tm1Lex mutation (0 available); any Map3k10 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:137358 )
• mice exhibit no morphological defects




Genotype
MGI:3801188
cx2
Allelic
Composition		 Map3k10tm1Lex/Map3k10tm1Lex
Map3k9tm1Lex/Map3k9tm1Lex
Genetic
Background		 either: 129S-Map3k10tm1Lex Map3k9tm1Lex or B6.129S-Map3k10tm1Lex Map3k9tm1Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k10tm1Lex mutation (0 available); any Map3k10 mutation (31 available)
Map3k9tm1Lex mutation (0 available); any Map3k9 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:137358 )
N
• despite a lack of compensation from Map3k11, mice have normal life spans

reproductive system
reproductive system phenotype ( J:137358 )
N
• despite a lack of compensation from Map3k11, mice breed normally
• despite expression in the testis, testicular development is normal

embryo
embryo phenotype ( J:137358 )
N
• despite a lack of compensation from Map3k11, mice develop normally

muscle
muscle phenotype ( J:137358 )
N
• despite expression in the femoral muscle, skeletal muscle organization is normal

nervous system
nervous system phenotype ( J:137358 )
N
• despite expression in the brain, nervous system development and cell death in the superior cervical ganglia are normal

renal/urinary system
renal/urinary system phenotype ( J:137358 )
N
• despite endogenous expression in the kidneys, renal morphology and function are normal

digestive/alimentary system
digestive/alimentary phenotype ( J:137358 )
N
• despite expression in the spleen and stomach, their morphology and function are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory