All Phenotypes Kat2a<tm3Roth> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kat2a^tm3Roth
targeted mutation 3, Sharon Y R Dent
MGI:3800306

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kat2a^tm3Roth/Kat2a^tm3Roth	involves: 129	MGI:3801408
hm2	Kat2a^tm3Roth/Kat2a^tm3Roth	involves: 129 * C57BL/6	MGI:3801321
ht3	Kat2a^tm3Roth/Kat2a⁺	involves: 129	MGI:3801409
ht4	Kat2a^tm1Roth/Kat2a^tm3Roth	129-Kat2a^tm1Roth/Kat2a^tm3Roth	MGI:3801324
ht5	Kat2a^tm3Roth/Kat2a^tm3.1Roth	involves: 129	MGI:3801323
ht6	Kat2a^tm1Roth/Kat2a^tm3Roth	involves: 129 * 129S7/SvEvBrd	MGI:3801410
ht7	Kat2a^tm1Roth/Kat2a^tm3Roth	involves: 129 * 129S7/SvEvBrd * C57BL/6	MGI:3801322
cx8	Atxn7^tm1Hzo/Atxn7⁺ Kat2a^tm3Roth/Kat2a^tm3Roth	involves: 129 * 129S7/SvEvBrd	MGI:5315447
cx9	Atxn7^tm1Hzo/Atxn7⁺ Kat2a^tm3Roth/Kat2a⁺	involves: 129 * 129S7/SvEvBrd	MGI:5315467

Allelic Composition	Kat2a^tm3Roth/Kat2a^tm3Roth
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat2a^tm3Roth mutation (0 available); any Kat2a mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal sternebra number ( J:137385 )

• some mice exhibit an extra sternebra between the fourth sternebra and the xiphoid process

• some mice had one or several fewer sternebrae even though extra sternebrae may have developed between the fourth sternebrae and xiphoid process upon transformation of L1 to T14

small xiphoid process ( J:137385 )

• in 86% of mice

increased rib number ( J:137385 )

• in some mice

rib fusion ( J:137385 )

• in some mice

vertebral transformation ( J:137385 )

• anterior skeletal transformation are not associated with prenatal lethality

thoracic vertebral transformation ( J:137385 )

• 70% of mice exhibit a T12 to T10 transformation

lumbar vertebral transformation ( J:137385 )

• at E18.5 and P0, 45% of mice exhibit a transformation of L1 to a thoracic segments

• 40% of mice exhibit L3 to L2 transformations while only one mouse exhibited anapophysis on L4

Allelic Composition	Kat2a^tm3Roth/Kat2a^tm3Roth
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat2a^tm3Roth mutation (0 available); any Kat2a mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:132940 )

• fewer than expected mice survive until weaning (2% compared to the expected 25%) with mice dying 10 to 21 days after birth

growth/size/body

decreased embryo size ( J:132940 )

• at E10.5

decreased body size ( J:132940 )

decreased body weight ( J:132940 )

• postnatally and after weaning

nervous system

open neural tube ( J:132940 )

• in 20% of mice at E18.5

exencephaly ( J:132940 )

• in 15% mice at E18.5

respiratory system

abnormal breathing pattern ( J:132940 )

• mice removed from mothers at E18.5 die within minutes with difficulty breathing

embryo

decreased embryo size ( J:132940 )

• at E10.5

open neural tube ( J:132940 )

• in 20% of mice at E18.5

Allelic Composition	Kat2a^tm3Roth/Kat2a⁺
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat2a^tm3Roth mutation (0 available); any Kat2a mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased lumbar vertebrae number ( J:137385 )

• in 3 of 15 mice

Allelic Composition	Kat2a^tm1Roth/Kat2a^tm3Roth
Genetic Background	129-Kat2a^tm1Roth/Kat2a^tm3Roth

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat2a^tm1Roth mutation (0 available); any Kat2a mutation (40 available)
Kat2a^tm3Roth mutation (0 available); any Kat2a mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

exencephaly ( J:132940 )

• Background Sensitivity: at E18.5 and on a pure 129 background, 100% of mice exhibit exencephaly compared to 19% on a predominantly C57BL/6 mixed background

Allelic Composition	Kat2a^tm3Roth/Kat2a^tm3.1Roth
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat2a^tm3.1Roth mutation (1 available); any Kat2a mutation (40 available)
Kat2a^tm3Roth mutation (0 available); any Kat2a mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

exencephaly ( J:132940 )

• in 38% mice at E18.5

respiratory system

abnormal breathing pattern ( J:132940 )

• mice removed from mothers at E18.5 die within minutes with difficulty breathing

Allelic Composition	Kat2a^tm1Roth/Kat2a^tm3Roth
Genetic Background	involves: 129 * 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal sternebra number ( J:137385 )

• all mice exhibit an extra sternebra between the fourth sternebra and the xiphoid process and some mice exhibit fewer sternebra in the sternum

small xiphoid process ( J:137385 )

• in all mice

increased rib number ( J:137385 )

rib fusion ( J:137385 )

• in some mice

thoracic vertebral transformation ( J:137385 )

• 90% of mice exhibit a T12 to T10 transformation while the remaining 10% exhibit a T13 to T10 transformation

lumbar vertebral transformation ( J:137385 )

• at E18.5 and P0, all mice exhibit a transformation of specific lumbar segments to anterior thoracic segments

• 85% of mice exhibit anapophysis on L3 indicating a conversion of L3 to L2 as well as exhibiting an L1 to T14 transformation

• 15% of mice exhibit anapophysis on L4

Allelic Composition	Kat2a^tm1Roth/Kat2a^tm3Roth
Genetic Background	involves: 129 * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:132940 )

• fewer than expected mice survive until weaning (1% compared to the expected 25%)

embryo

decreased embryo size ( J:132940 )

• at E10.5

abnormal neural tube closure ( J:132940 )

• Background Sensitivity: on predominantly C57BL/6 mixed background 19% of mice exhibit neural tube closure defect at E18.5

open neural tube ( J:132940 )

• at E9.5, some mice exhibit open neural tubes

• at E18.5, 42% of mice exhibit open neural tubes

nervous system

nervous system phenotype ( J:132940 )

N	• despite exencephaly, mice exhibit normal neural cell death and proliferation and normal neural crest formation and migration

abnormal neural tube closure ( J:132940 )

• Background Sensitivity: on predominantly C57BL/6 mixed background 19% of mice exhibit neural tube closure defect at E18.5

open neural tube ( J:132940 )

• at E9.5, some mice exhibit open neural tubes

• at E18.5, 42% of mice exhibit open neural tubes

exencephaly ( J:132940 )

• at E9.5 to E10.5, 40% to 50% of mice exhibit open anterior neural tubes with no gender bias

growth/size/body

decreased embryo size ( J:132940 )

• at E10.5

decreased body size ( J:132940 )

• in the one mouse that survives past weaning

decreased fetal size ( J:132940 )

• by 20% at E18.5

respiratory system

respiratory system phenotype ( J:132940 )

N	• despite abnormal breathing, mice exhibit normal lung morphology

abnormal breathing pattern ( J:132940 )

• mice removed from mothers at E18.5 die within minutes with difficulty breathing

behavior/neurological

hunched posture ( J:132940 )

• in the one mouse that survives past weaning

vision/eye

blepharoptosis ( J:132940 )

• in the one mouse that survives past weaning

Allelic Composition	Atxn7^tm1Hzo/Atxn7⁺ Kat2a^tm3Roth/Kat2a^tm3Roth
Genetic Background	involves: 129 * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atxn7^tm1Hzo mutation (1 available); any Atxn7 mutation (38 available)
Kat2a^tm3Roth mutation (0 available); any Kat2a mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:179021 )

• double mutants with 100 CAG repeats in Atxn7 die at P1

Allelic Composition	Atxn7^tm1Hzo/Atxn7⁺ Kat2a^tm3Roth/Kat2a⁺
Genetic Background	involves: 129 * 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:179021 )

• double mutants with 100 CAG repeats in Atxn7 do not survive past 25 months of age

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