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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox5tm2.1Vlf
targeted mutation 2.1, Veronique Lefebvre
MGI:3799355
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sox5tm2.1Vlf/Sox5tm2.1Vlf involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J * SJL MGI:3800350


Genotype
MGI:3800350
hm1
Allelic
Composition		 Sox5tm2.1Vlf/Sox5tm2.1Vlf
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox5tm2.1Vlf mutation (0 available); any Sox5 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

skeleton
abnormal thoracic cage shape ( J:137217 )
• narrow thoracic cage
abnormal cervical vertebrae morphology ( J:137217 )
• delayed mineralization of cervical vertebral bodies
abnormal sternum ossification ( J:137217 )
• irregularly mineralized

craniofacial
palatal shelves fail to meet at midline ( J:137217 )
• failure of the palatal shelves and pterigoid processes to move toward the midline

digestive/alimentary system
palatal shelves fail to meet at midline ( J:137217 )
• failure of the palatal shelves and pterigoid processes to move toward the midline

growth/size/body
palatal shelves fail to meet at midline ( J:137217 )
• failure of the palatal shelves and pterigoid processes to move toward the midline
cleft secondary palate ( J:137217 )




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory