Analysis Tools
behavior/neurological
| N |
• mice exhibit normal cocaine self-administration
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Allele Symbol Allele Name Allele ID |
Ppp1r1btm4Pggd targeted mutation 4, Paul Greengard MGI:3799291 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal cocaine self-administration
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit decreased motivation for food reward compared to wild-type mice
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• locomotor sensitization to cocaine or morphine is less pronounced than in wild-type mice
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• while mice react normally to cocaine, mice display a decreased acute locomotor response to treatment with morphine compared to similarly treated wild-type mice
• locomotor sensitization to cocaine or morphine is less pronounced than in wild-type mice
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• mutant mice fail to exhibit conditioned place preference to cocaine
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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