Phenotypes associated with this allele

• Allele Symbol: Ppp1r1b^tm4Pggd
• Allele Name: targeted mutation 4, Paul Greengard
• Allele ID: MGI:3799291
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppp1r1b^tm4Pggd/Ppp1r1b^tm4Pggd	involves: 129 * C57BL/6	MGI:3802517
hm2	Ppp1r1b^tm4Pggd/Ppp1r1b^tm4Pggd	Not Specified	MGI:3802515

Genotype
MGI:3802517

hm1

• Allelic Composition: Ppp1r1b^tm4Pggd/Ppp1r1b^tm4Pggd
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:106270 )

N • mice exhibit normal cocaine self-administration

Genotype
MGI:3802515

hm2

• Allelic Composition: Ppp1r1b^tm4Pggd/Ppp1r1b^tm4Pggd
• Genetic Background: Not Specified

behavior/neurological

abnormal behavior ( J:137074 )

• mice exhibit decreased motivation for food reward compared to wild-type mice

impaired behavioral response to cocaine ( J:137074 )

• locomotor sensitization to cocaine or morphine is less pronounced than in wild-type mice

impaired behavioral response to morphine ( J:137074 )

• while mice react normally to cocaine, mice display a decreased acute locomotor response to treatment with morphine compared to similarly treated wild-type mice

• locomotor sensitization to cocaine or morphine is less pronounced than in wild-type mice

impaired conditioned place preference behavior ( J:137074 )

• mutant mice fail to exhibit conditioned place preference to cocaine