Analysis Tools
immune system
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• while the ratio of mature B cells in the spleen is decreases the ratio immature B cells are increased compared to in wild-type mice including a 1.5- to 2-fold increase in the ratio of marginal zone B cells
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• mice have fewer mature lymphocytes than wild-type mice
• however, the number of immature lymphocytes is normal
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• the number of mature B cells in the lymph node is decreased by 50% compared to in wild-type mice
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• mice possesses fewer CD4+ T cells in the spleen and lymph nodes than in wild-type mice
• however, the number of CD4+ T cells in the thymus and bone marrow is normal
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• mice possesses fewer CD8+ T cells in the spleen and lymph nodes than in wild-type mice
• however, the number of CD8+ T cells in the thymus and bone marrow is normal
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• B cell migration rates are higher than in wild-type mice
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• following stimulation with B7.6 or an anti-BCR antibody, B cell proliferation is reduced compared to in similarly treated wild-type mice
• however, B cell proliferation in response to LPS is normal
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• basal T cell migration rates and rates in response to Cxcl12 are higher than for wild-type cells
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• following stimulation with anti-CD3 antibodies, anti-CD3 and anti-CD28 antibodies or ConA, T cell proliferation is reduced compared to in wild-type mice
• however, T cell proliferation stimulated by PMA with ionomycin is normal
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• following immunized with TNP-KLH or TNP-Ficoll, mice produce less antibodies, IgM and IgG3 than similarly treated wild-type mice
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• following stimulation with anti-CD3 antibodies or ConA, IL-2 secretion is reduced compared to in similarly treated wild-type mice
• however, IL-2 production in response to PMA with ionomycin is normal
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hematopoietic system
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• while the ratio of mature B cells in the spleen is decreases the ratio immature B cells are increased compared to in wild-type mice including a 1.5- to 2-fold increase in the ratio of marginal zone B cells
|
|
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• mice have fewer mature lymphocytes than wild-type mice
• however, the number of immature lymphocytes is normal
|
|
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• the number of mature B cells in the lymph node is decreased by 50% compared to in wild-type mice
|
|
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• mice possesses fewer CD4+ T cells in the spleen and lymph nodes than in wild-type mice
• however, the number of CD4+ T cells in the thymus and bone marrow is normal
|
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• mice possesses fewer CD8+ T cells in the spleen and lymph nodes than in wild-type mice
• however, the number of CD8+ T cells in the thymus and bone marrow is normal
|
|
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• B cell migration rates are higher than in wild-type mice
|
|
|
• following stimulation with B7.6 or an anti-BCR antibody, B cell proliferation is reduced compared to in similarly treated wild-type mice
• however, B cell proliferation in response to LPS is normal
|
|
|
• basal T cell migration rates and rates in response to Cxcl12 are higher than for wild-type cells
|
|
|
• following stimulation with anti-CD3 antibodies, anti-CD3 and anti-CD28 antibodies or ConA, T cell proliferation is reduced compared to in wild-type mice
• however, T cell proliferation stimulated by PMA with ionomycin is normal
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cellular
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• following stimulation with B7.6 or an anti-BCR antibody, B cell proliferation is reduced compared to in similarly treated wild-type mice
• however, B cell proliferation in response to LPS is normal
|
|
|
• following stimulation with anti-CD3 antibodies, anti-CD3 and anti-CD28 antibodies or ConA, T cell proliferation is reduced compared to in wild-type mice
• however, T cell proliferation stimulated by PMA with ionomycin is normal
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