All Phenotypes Asgr1<tm1Sau> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Asgr1^tm1Sau
targeted mutation 1, Brian Sauer
MGI:3798982

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Asgr1^tm1Sau/Asgr1^tm1Sau	B6.129S4-Asgr1^tm1Sau	MGI:3804626
cx2	Asgr1^tm1Sau/Asgr1^tm1Sau St3gal4^tm1.1Jxm/St3gal4^tm1.1Jxm	B6.129-St3gal4^tm1.1Jxm Asgr2^tm1Her	MGI:3804624

Allelic Composition	Asgr1^tm1Sau/Asgr1^tm1Sau
Genetic Background	B6.129S4-Asgr1^tm1Sau

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Asgr1^tm1Sau mutation (1 available); any Asgr1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:136946 )

• following infection with S. pneumoniae, mice exhibit decreased survival compared to similarly treated wild-type mice

homeostasis/metabolism

decreased bleeding time ( J:136946 )

immune system

increased susceptibility to bacterial infection ( J:136946 )

• following infection with S. pneumoniae, mice exhibit decreased survival compared to similarly treated wild-type mice

• following infection with S. pneumoniae, mice exhibit hemorrhage of the spleen, increased hepatocyte cell death, and increased vascular occlusion and fibrin deposition in the kidney and liver compared to similarly treated wild-type mice

Allelic Composition	Asgr1^tm1Sau/Asgr1^tm1Sau St3gal4^tm1.1Jxm/St3gal4^tm1.1Jxm
Genetic Background	B6.129-St3gal4^tm1.1Jxm Asgr2^tm1Her

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Asgr1^tm1Sau mutation (1 available); any Asgr1 mutation (15 available)
St3gal4^tm1.1Jxm mutation (1 available); any St3gal4 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:136946 )

N	• unlike in St3gal4^tm1.1Jxm homozygotes, platelet counts are normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:136946 )

N	• unlike either single homozygote, mice exhibit normal bleed times

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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