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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dgcr8Gt(XH157)Byg
gene trap XH157, BayGenomics
MGI:3798965
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Dgcr8Gt(XH157)Byg/Dgcr8+ B6.129P2-Dgcr8Gt(XH157)Byg MGI:5451009
ht2
 		Dgcr8Gt(XH157)Byg/Dgcr8+ involves: 129P2/OlaHsd * C57BL/6J MGI:3802830
cx3
 		Dgcr8Gt(XH157)Byg/Dgcr8+
Tg(Thy1-EGFP)MJrs/0 		involves: 129P2/OlaHsd * C57BL/6J * CBA MGI:3802829


Genotype
MGI:5451009
ht1
Allelic
Composition		 Dgcr8Gt(XH157)Byg/Dgcr8+
Genetic
Background		 B6.129P2-Dgcr8Gt(XH157)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgcr8Gt(XH157)Byg mutation (1 available); any Dgcr8 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
enhanced long-term potentiation ( J:190908 )
• increased at 16 weeks of age but not at 8-10 weeks of age
• however, basal synaptic transmission is normal




Genotype
MGI:3802830
ht2
Allelic
Composition		 Dgcr8Gt(XH157)Byg/Dgcr8+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgcr8Gt(XH157)Byg mutation (1 available); any Dgcr8 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal spatial working memory ( J:136969 )
• mice exhibit decreased arm choice accuracy compared to wild-type mice

nervous system
abnormal dendrite morphology ( J:136969 )
• mice exhibit a reduction in the number of dendritic spines and mushroom spine dendritic complexity of CA1 pyramidal neurons compared to in wild-type mice
decreased prepulse inhibition ( J:136969 )
• mice exhibit a deficit in prepulse inhibition compared to in wild-type mice

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:136969 )
N
• despite abnormal prepulse inhibition, mice exhibit normal hearing




Genotype
MGI:3802829
cx3
Allelic
Composition		 Dgcr8Gt(XH157)Byg/Dgcr8+
Tg(Thy1-EGFP)MJrs/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgcr8Gt(XH157)Byg mutation (1 available); any Dgcr8 mutation (69 available)
Tg(Thy1-EGFP)MJrs mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dendrite morphology ( J:136969 )
• while length is normal, mushroom spine width in the CA1 pyramidal spines is decreased compared to in wild-type mice
• complexity of the basal dendritic tree of pyramidal neurons is reduced compared to in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory