Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgcr8Gt(XH157)Byg mutation
(1 available);
any
Dgcr8 mutation
(67 available)
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nervous system
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• increased at 16 weeks of age but not at 8-10 weeks of age
• however, basal synaptic transmission is normal
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Allelic
Composition |
Dgcr8Gt(XH157)Byg/Dgcr8+
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgcr8Gt(XH157)Byg mutation
(1 available);
any
Dgcr8 mutation
(67 available)
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behavior/neurological
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• mice exhibit decreased arm choice accuracy compared to wild-type mice
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nervous system
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• mice exhibit a reduction in the number of dendritic spines and mushroom spine dendritic complexity of CA1 pyramidal neurons compared to in wild-type mice
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• mice exhibit a deficit in prepulse inhibition compared to in wild-type mice
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hearing/vestibular/ear
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N |
• despite abnormal prepulse inhibition, mice exhibit normal hearing
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgcr8Gt(XH157)Byg mutation
(1 available);
any
Dgcr8 mutation
(67 available)
Tg(Thy1-EGFP)MJrs mutation
(1 available)
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nervous system
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• while length is normal, mushroom spine width in the CA1 pyramidal spines is decreased compared to in wild-type mice
• complexity of the basal dendritic tree of pyramidal neurons is reduced compared to in wild-type mice
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Analysis Tools
