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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcf4tm1.1Hmb
targeted mutation 1.1, Dan Holmberg
MGI:3798811
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tcf4tm1.1Hmb/Tcf4tm1.1Hmb involves: 129P2/OlaHsd * C57BL/6J MGI:3803022
ht2
 		Tcf4tm1.1Hmb/Tcf4+ involves: 129P2/OlaHsd * C57BL/6J MGI:3803023


Genotype
MGI:3803022
hm1
Allelic
Composition		 Tcf4tm1.1Hmb/Tcf4tm1.1Hmb
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf4tm1.1Hmb mutation (0 available); any Tcf4 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system
immune system phenotype ( J:136143 )
N
• thymus cellularity and gamma delta T cells are normal
abnormal T cell differentiation ( J:136143 )
• T cell development is partially blocked at DN3 stage
increased double-negative T cell number ( J:136143 )
• despite normal overall proliferation and apoptosis rates, DN3 cells accumulate more than in wild-type mice
abnormal T cell physiology ( J:136143 )
• thymocytes are more sensitive to anti-CD3 induced apoptosis than wild-type cells
• thymocytes are at a disadvantage to reconstitute T cell compartments compared to wild-type cells

hematopoietic system
abnormal T cell differentiation ( J:136143 )
• T cell development is partially blocked at DN3 stage
increased double-negative T cell number ( J:136143 )
• despite normal overall proliferation and apoptosis rates, DN3 cells accumulate more than in wild-type mice
abnormal T cell physiology ( J:136143 )
• thymocytes are more sensitive to anti-CD3 induced apoptosis than wild-type cells
• thymocytes are at a disadvantage to reconstitute T cell compartments compared to wild-type cells




Genotype
MGI:3803023
ht2
Allelic
Composition		 Tcf4tm1.1Hmb/Tcf4+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf4tm1.1Hmb mutation (0 available); any Tcf4 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased double-negative T cell number ( J:136143 )
• mice exhibit an intermediate increased in DN3 cells compared to wild-type mice and homozygotes

hematopoietic system
increased double-negative T cell number ( J:136143 )
• mice exhibit an intermediate increased in DN3 cells compared to wild-type mice and homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory