Phenotypes associated with this allele

• Allele Symbol: Tg(Igh-3VD93)343Ust
• Allele Name: transgene insertion 343, Ursula Storb
• Allele ID: MGI:3798613
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Igh-3VD93)343Ust/?	involves: C57BL/6 * SJL	MGI:3798828

Genotype
MGI:3798828

tg1

• Allelic Composition: Tg(Igh-3VD93)343Ust/?
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell morphology ( J:135209 )

• splenic B cells co-express gamma 2b (Igh-3) and mu (Igh-6) on all Igh-3+ cells

• membrane Igh-3 levels are higher than membrane Igh-6 levels in 12 day old fetal liver cells

decreased pre-B cell number ( J:135209 )

• less than 1% of splenic lymphocytes are either mu or kappa positive in neonatal mice

• by 4 weeks of age, mice exhibit approximately 5 fold fewer mu or kappa positive cells in the spleen, however, by 16 weeks B cells increase to near normal numbers

• B220(lo), mIg- bone marrow cells contain fewer small pre-B cells than control (69-80% vs. 44-56%)

hematopoietic system

abnormal B cell morphology ( J:135209 )

• splenic B cells co-express gamma 2b (Igh-3) and mu (Igh-6) on all Igh-3+ cells

• membrane Igh-3 levels are higher than membrane Igh-6 levels in 12 day old fetal liver cells

decreased pre-B cell number ( J:135209 )

• less than 1% of splenic lymphocytes are either mu or kappa positive in neonatal mice

• by 4 weeks of age, mice exhibit approximately 5 fold fewer mu or kappa positive cells in the spleen, however, by 16 weeks B cells increase to near normal numbers

• B220(lo), mIg- bone marrow cells contain fewer small pre-B cells than control (69-80% vs. 44-56%)