About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pcdhatm3Tyag
targeted mutation 3, Takeshi Yagi
MGI:3797610
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pcdhatm3Tyag/Pcdhatm3Tyag B6.Cg-Pcdhatm3Tyag MGI:4356106
hm2
 		Pcdhatm3Tyag/Pcdhatm3Tyag involves: C57BL/6 MGI:3799112
cx3
 		Or8a1tm25Mom/?
Or8a1btm6Mom/?
Pcdhatm3Tyag/Pcdhatm3Tyag 		involves: 129P2/OlaHsd * C57BL/6 MGI:3799116
cx4
 		Or10j5tm1Mom/?
Pcdhatm3Tyag/Pcdhatm3Tyag 		involves: C57BL/6 MGI:3799113
cx5
 		Or8a1tm25Mom/?
Pcdhatm3Tyag/Pcdhatm3Tyag 		involves: C57BL/6 MGI:3799114


Genotype
MGI:4356106
hm1
Allelic
Composition		 Pcdhatm3Tyag/Pcdhatm3Tyag
Genetic
Background		 B6.Cg-Pcdhatm3Tyag
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcdhatm3Tyag mutation (8 available); any Pcdha mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:151979 )
N
• cortical barrel fields are structurally normal
abnormal substantia nigra morphology ( J:151979 )
• the density of serotonergic fibers is increased in the peripheral region and decreased in the central region compared to in wild-type mice
abnormal globus pallidus morphology ( J:151979 )
• the density of serotonergic fibers is increased in the peripheral region and decreased in the central region compared to in wild-type mice
abnormal dorsal striatum morphology ( J:151979 )
• the density of serotonergic fibers is decreased in the caudate putamen compared to in wild-type mice
abnormal thalamus morphology ( J:151979 )
• serotonergic fibers accumulate around the dorsal lateral geniculate nucleus and the medial geniculate nucleus but are sparse in the central regions of these nuclei unlike in wild-type mice
abnormal lateral geniculate nucleus morphology ( J:151979 )
• serotonergic fibers accumulate around the dorsal lateral geniculate nucleus and the medial geniculate nucleus but are sparse in the central regions of these nuclei unlike in wild-type mice
abnormal medial geniculate nucleus morphology ( J:151979 )
• serotonergic fibers accumulate around the dorsal lateral geniculate nucleus and the medial geniculate nucleus but are sparse in the central regions of these nuclei unlike in wild-type mice
abnormal cingulate gyrus morphology ( J:151979 )
• mice exhibit decreased density of serotonergic fibers in the cingulate cortex compared with wild-type mice
abnormal entorhinal cortex morphology ( J:151979 )
• the density of serotonergic fibers are greater in the entorhinal cortex compared to in wild-type mice
abnormal hippocampus morphology ( J:151979 )
• serotonergic fibers are increased in the lacunosum-moleculare (184%) and the stratum radiatum (134%) of the CA1 region compared to in wild-type mice
• serotonergic fibers are decreased in the stratum oriens (44%) and dentage gyrus (21%) compared to in wild-type mice
abnormal dentate gyrus morphology ( J:151979 )
• serotonergic fibers are decreased 21% in the dentage gyrus compared to in wild-type mice
abnormal primary motor cortex morphology ( J:151979 )
• in the rostral part of the primary motor cortex, serotonergic fibers more densely innervated layer I and short, clumped fibers are frequently observed in layer II/III of only the most rostral part of the primary motor cortex compared to in wild-type mice
abnormal olfactory bulb morphology ( J:151979 )
• mice exhibit fewer serotonergic fibers in the layers encompassed by and including the external and internal plexiform layers compared to in wild-type mice
• mice exhibit more serotonergic fibers in the granule cell layer compared to in wild-type mice
abnormal serotonergic neuron morphology ( J:151979 )
• mice exhibit abnormal serotonergic fibers in the cerebral cortex, hippocampus, basal ganglia, and thalamus compared to in wild-type mice

behavior/neurological
increased grooming behavior ( J:151979 )
• resulting in lesions

growth/size/body
decreased body weight ( J:151979 )
• at 72 to 84 weeks

homeostasis/metabolism
increased serotonin level ( J:151979 )
• at 10 weeks, the level of serotonin is higher in the hippocampus compared to in wild-type mice

integument
skin lesions ( J:151979 )
• by 36 weeks, mice develop lesions on their head, neck, and snout unlike in wild-type mice




Genotype
MGI:3799112
hm2
Allelic
Composition		 Pcdhatm3Tyag/Pcdhatm3Tyag
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcdhatm3Tyag mutation (8 available); any Pcdha mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:136920 )
• more, small glomeruli are present




Genotype
MGI:3799116
cx3
Allelic
Composition		 Or8a1tm25Mom/?
Or8a1btm6Mom/?
Pcdhatm3Tyag/Pcdhatm3Tyag
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1btm6Mom mutation (4 available); any Or8a1b mutation (35 available)
Or8a1tm25Mom mutation (6 available); any Or8a1 mutation (69 available)
Pcdhatm3Tyag mutation (8 available); any Pcdha mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:136920 )
• labeled axons form multiple glomeruli but none of the olfactory sensory neurons express both GFP and lacZ indicating olfactory receptor gene choice is not perturbed




Genotype
MGI:3799113
cx4
Allelic
Composition		 Or10j5tm1Mom/?
Pcdhatm3Tyag/Pcdhatm3Tyag
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or10j5tm1Mom mutation (5 available); any Or10j5 mutation (46 available)
Pcdhatm3Tyag mutation (8 available); any Pcdha mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:136920 )
• more, small glomeruli are present
abnormal olfactory bulb development ( J:136920 )
• at P7, coalescence of MOR23 axons into glomeruli is disturbed with the average number of labeled glomeruli increased to 3.3 and 2.2 in the lateral and medial half-bulbs, respectively compared to 1.0 and 1.1 in wild-type controls
• several of these glomeruli appear smaller than in controls
• however, almost all glomeruli appear homogeneous




Genotype
MGI:3799114
cx5
Allelic
Composition		 Or8a1tm25Mom/?
Pcdhatm3Tyag/Pcdhatm3Tyag
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1tm25Mom mutation (6 available); any Or8a1 mutation (69 available)
Pcdhatm3Tyag mutation (8 available); any Pcdha mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:136920 )
• more, small glomeruli are present
abnormal olfactory bulb development ( J:136920 )
• at P7, coalescence of M71 axons into glomeruli is disturbed with the average number of labeled glomeruli increased to 5.4 and 3.0 in the lateral and medial half-bulbs, respectively compared to 1.0 and 1.3 in heterozygous and wild-type controls
• several of these glomeruli appear smaller than in controls
• at P30, almost all mice still show more than 3 glomeruli per half-bulb and fewer glomeruli appear homogeneous
• at P60 multiple small glomeruli persist




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory