Phenotypes associated with this allele

• Allele Symbol: Ppbp^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:3797508
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppbp^tm1(KOMP)Vlcg/Ppbp^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:5514233

Genotype
MGI:5514233

hm1

• Allelic Composition: Ppbp^{tm1(KOMP)Vlcg}/Ppbp^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:198197 )

N • under normal conditions, mice exhibit normal platelet thrombotic response and GR1+ leukocyte rolling or recruitment to thrombi

abnormal leukocyte physiology ( J:198197 )

• following vascular injury, mice exhibit a major reduction in leukocyte shape change and leukocyte migration through thrombi compared with wild-type mice

abnormal leukocyte migration ( J:198197 )

• impaired migration following vascular injury

homeostasis/metabolism

abnormal response to injury ( J:198197 )

• following vascular injury, mice exhibit a major reduction in leukocyte shape change and leukocyte migration through thrombi compared with wild-type mice

cellular

abnormal leukocyte migration ( J:198197 )

• impaired migration following vascular injury

hematopoietic system

abnormal leukocyte physiology ( J:198197 )

• following vascular injury, mice exhibit a major reduction in leukocyte shape change and leukocyte migration through thrombi compared with wild-type mice

abnormal leukocyte migration ( J:198197 )

• impaired migration following vascular injury