Phenotypes associated with this allele

• Allele Symbol: Epha6^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3797071
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epha6^tm1Lex/Epha6^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3806691

Genotype
MGI:3806691

hm1

• Allelic Composition: Epha6^tm1Lex/Epha6^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:136714 )

• freezing is decreased relative to wild-type controls when placed in the training context 24h after training

abnormal cued conditioning behavior ( J:136714 )

• while freezing increased across trials, freezing to tone was decreased relative to wild-type controls

• however, no differences are detected in motor activity, auditory reactivity or pain responsiveness

abnormal inhibitory learning ( J:136714 )

• on the first day of reversal training homozygotes took longer to learn the new platform location compared to wild-type controls

abnormal spatial learning ( J:136714 )

• while escape latency decreases across trials in a Morris water maze, performance is impaired relative to wild-type controls

• however, no difference is detected in swim speed or distance traveled