Phenotypes associated with this allele

• Allele Symbol: Il7^m1Jyen
• Allele Name: mutation 1, Jeffrey Jong-Young Yen
• Allele ID: MGI:3797070
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il7^m1Jyen/Il7^m1Jyen	involves: C3H * C57BL/6	MGI:3797081

Genotype
MGI:3797081

hm1

• Allelic Composition: Il7^m1Jyen/Il7^m1Jyen
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

thymus hypoplasia ( J:136470 )

• the thymus is severely atrophic with a 10-fold reduction in numbers

decreased B cell number ( J:136470 )

• there is a 27 fold reduction in the percentage of B220-positive B cells found in circulation

• the spleen and bone marrow also have significantly less B cells

decreased single-positive T cell number ( J:136470 )

• there is a 9-fold reduction in the percentage of T cells found in circulation

• the spleen and bone marrow also have significantly less T cells

abnormal myeloid leukocyte morphology ( J:136470 )

• there is a large increase in the percentage of CD11b-positive/Gr1-positive myeloid cells found in circulation

• this increase results from lower percentages of lymphocytes found in the blood and not from higher numbers

spleen hypoplasia ( J:136470 )

• there is a slight reduction in the number of spleen cells

lymph node hypoplasia ( J:136470 )

• lymph nodes are reduced in size with a 20-fold decrease in the size of numbers

hematopoietic system

thymus hypoplasia ( J:136470 )

• the thymus is severely atrophic with a 10-fold reduction in numbers

decreased B cell number ( J:136470 )

• there is a 27 fold reduction in the percentage of B220-positive B cells found in circulation

• the spleen and bone marrow also have significantly less B cells

decreased single-positive T cell number ( J:136470 )

• there is a 9-fold reduction in the percentage of T cells found in circulation

• the spleen and bone marrow also have significantly less T cells

abnormal myeloid leukocyte morphology ( J:136470 )

• there is a large increase in the percentage of CD11b-positive/Gr1-positive myeloid cells found in circulation

• this increase results from lower percentages of lymphocytes found in the blood and not from higher numbers

spleen hypoplasia ( J:136470 )

• there is a slight reduction in the number of spleen cells

endocrine/exocrine glands

thymus hypoplasia ( J:136470 )

• the thymus is severely atrophic with a 10-fold reduction in numbers