Analysis Tools
homeostasis/metabolism
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• significantly impaired compared to wild-type
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Allele Symbol Allele Name Allele ID |
Tg(FLII)1Hdc transgene insertion 1, Hugh D Campbell MGI:3796829 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• significantly impaired compared to wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• wound areas are significantly larger in transgenic mice than controls at 3 and 7 days post-wounding
• wound length and dermal gape are increased relative to controls at 3 and 7 days after wounding
• scratch wounds in confluent fibroblast cultures close faster in wild-type cultures than in transgenic cultures
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• wound length and dermal gape are increased relative to controls at 3 and 7 days after wounding
• length of neoepidermis is similar to controls, but percentage of re-epithelialization at 3 days after wounding is significantly decreased
• cell proliferation within epidermis of wounds is similar in wild-type, Flii-deficient heterozygous mice and transgenic mice, but significantly fewer proliferating cells are detected in dermis of wounds in transgenic mice at 7 days after wounding
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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