Phenotypes associated with this allele

• Allele Symbol: Crybb2⁰³⁷⁷
• Allele Name: mutant line 0377
• Allele ID: MGI:3796239
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crybb2^0377/Crybb2^0377	involves: C3H * C57BL/6Ei	MGI:3809416
ht2	Crybb2^0377/Crybb2^+	involves: C3H * C57BL/6Ei	MGI:3809415

Genotype
MGI:3809416

hm1

• Allelic Composition: Crybb2⁰³⁷⁷/Crybb2⁰³⁷⁷
• Genetic Background: involves: C3H * C57BL/6Ei

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens morphology ( J:136138 )

• mice exhibit central fiber cells that are detached from the anterior epithelium and cells in the equatorial zone that are misshaped and disoriented

cataract ( J:136138 )

• cataracts are progress to large vacuoles in the center and to a stop of elongation in the equatorial region

small lens ( J:136138 )

nervous system

increased Purkinje cell number ( J:136138 )

• mice exhibit an 11% increase in the number of Purkinje cells in the cerebellum compared to in wild-type mice

decreased Purkinje cell size ( J:136138 )

• Purkinje cells are often smaller than in wild-type mice

Genotype
MGI:3809415

ht2

• Allelic Composition: Crybb2⁰³⁷⁷/Crybb2⁺
• Genetic Background: involves: C3H * C57BL/6Ei

vision/eye

abnormal lens morphology ( J:136138 )

• at P4, fiber cell nuclei are not fully degraded and remain present at the center of the lens

cataract ( J:136138 )

• mice exhibit progressive cataracts

• at P21, cataracts are progressed to vacuoles in the center and to a stop of elongation in the equatorial region

small lens ( J:136138 )