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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Irak2tm1Aki
targeted mutation 1, Shizuo Akira
MGI:3796171
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Irak2tm1Aki/Irak2tm1Aki involves: 129/Sv * C57BL/6 MGI:3807960
cx2
 		Irak1tm1Jth/Y
Irak2tm1Aki/Irak2tm1Aki 		involves: 129/Sv * C57BL/6 MGI:3807961


Genotype
MGI:3807960
hm1
Allelic
Composition		 Irak2tm1Aki/Irak2tm1Aki
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak2tm1Aki mutation (0 available); any Irak2 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:136290 )
• production of Il6, Tnf and the chemokine KC is abrogated in macrophages after LPS or CpG DNA stimulation
decreased susceptibility to endotoxin shock ( J:136290 )
• mice are completely resistant to septic shock induced by LPS or CpG DNA unlike wild-type which succumb to shock

hematopoietic system
abnormal macrophage physiology ( J:136290 )
• production of Il6, Tnf and the chemokine KC is abrogated in macrophages after LPS or CpG DNA stimulation




Genotype
MGI:3807961
cx2
Allelic
Composition		 Irak1tm1Jth/Y
Irak2tm1Aki/Irak2tm1Aki
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak1tm1Jth mutation (0 available); any Irak1 mutation (16 available)
Irak2tm1Aki mutation (0 available); any Irak2 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:136290 )
• thioglcollate-elicited peritoneal macrophages show impaired production of Il6, Tnf and the chemokine KC, upon stimulation by TLR ligands such as LPS or CpG DNA, but response to poly(I:C) is comparable to wild-type
abnormal dendritic cell physiology ( J:136290 )
• cytokine production in response to TLR ligands such as LPS or CpG DNA is defective
decreased susceptibility to endotoxin shock ( J:136290 )
• after challenge with LPS or CpG DNA together with D-galactosamine, no mutants died in contrast to 100% mortality of wild-type to endotoxic shock

hematopoietic system
abnormal macrophage physiology ( J:136290 )
• thioglcollate-elicited peritoneal macrophages show impaired production of Il6, Tnf and the chemokine KC, upon stimulation by TLR ligands such as LPS or CpG DNA, but response to poly(I:C) is comparable to wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory