Analysis Tools
homeostasis/metabolism
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• mice exhibit an increase brain lathosterol levels compared with wild-type mice
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Allele Symbol Allele Name Allele ID |
Abcg4tm1Dgen targeted mutation 1, Deltagen MGI:3795864 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit an increase brain lathosterol levels compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• astrocytes exhibit a moderate increase in cholesterol mass compared with wild-type cells
• astrocyte cholesterol efflux is decreased compared to in wild-type cells
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• astrocytes exhibit decreased sterol synthesis compared with wild-type cells
• astrocyte desmosterol efflux is decreased compared to in wild-type cells
• astrocyte HDL-dependent desmosterol efflux is decreased compared to in wild-type cells
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• desmosterol levels are increased 2-fold in astrocytes compared to in wild-type cells
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• astrocytes exhibit a moderate increase in cholesterol mass compared with wild-type cells
• astrocyte cholesterol efflux is decreased compared to in wild-type cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• astrocytes exhibit a moderate increase in cholesterol mass compared with wild-type cells
• astrocyte cholesterol efflux is decreased compared to in wild-type cells
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• astrocytes exhibit decreased sterol synthesis compared with wild-type cells
• astrocyte desmosterol efflux is decreased compared to in wild-type cells
• astrocyte HDL-dependent desmosterol efflux is decreased compared to in wild-type cells
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• desmosterol levels are increased 2-fold in astrocytes compared to in wild-type cells
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• astrocytes exhibit a moderate increase in cholesterol mass compared with wild-type cells
• astrocyte cholesterol efflux is decreased compared to in wild-type cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• astrocytes exhibit a moderate increase in cholesterol mass compared with wild-type cells
• astrocyte cholesterol efflux is decreased compared to in wild-type cells
• HDL-dependent cholesterol efflux in astrocytes is decreased compared to in wild-type cells
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• astrocytes exhibit decreased sterol synthesis compared with wild-type cells
• astrocyte desmosterol efflux is decreased compared to in wild-type cells
• astrocyte HDL-dependent desmosterol efflux is decreased compared to in wild-type cells
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• cholesterol tracer transfer from astrocytes to neurons is decreased compared to in wild-type cells
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• mice exhibit a 2.4-fold increase in brain desmosterol levels compared with wild-type mice
• brain lanosterol, lathosterol, and 27-OH-cholesterol levels are increased by 1.9-, 1.5-, and 1.7-fold, respectively, compared with wild-type mice
• however, mice exhibit normal levels of brain cholesterol, 24(S)-OH-cholesterol, and plant sterol levels
• desmosterol levels are increased 4-fold in astrocytes compared to in wild-type cells
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• astrocytes exhibit a moderate increase in cholesterol mass compared with wild-type cells
• astrocyte cholesterol efflux is decreased compared to in wild-type cells
• HDL-dependent cholesterol efflux in astrocytes is decreased compared to in wild-type cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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