Phenotypes associated with this allele

• Allele Symbol: Best1^tm1Lmar
• Allele Name: targeted mutation 1, Lihua Marmorstein
• Allele ID: MGI:3795281
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Best1^tm1Lmar/Best1^tm1Lmar	involves: 129X1/SvJ * C57BL/6	MGI:3797408

Genotype
MGI:3797408

hm1

• Allelic Composition: Best1^tm1Lmar/Best1^tm1Lmar
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal eye physiology ( J:136113 )

• following treatment with 100 uM ATP, retinal pigment epithelial cells exhibit a slow monophasic rise in intracellular free calcium ions that is greater than in wild-type cell

• however, calcium ion-induced chloride ion currents are normal

abnormal eye electrophysiology ( J:136113 )

• at 2 to 6 months of age, the light peak recorded on an electroretinogram are larger than for wild-type mice

• mice exhibit a reversal of polarity in the response at low stimulus compared to wild-type mice

• the light peak is more sensitive to treatment with nimodipine than in wild-type mice