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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Serpina10tm1Gjb
targeted mutation 1, George J Broze
MGI:3795215
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Serpina10tm1Gjb/Serpina10tm1Gjb involves: 129X1/SvJ * C57BL/6 MGI:3804658
cx2
 		F5tm2Dgi/F5tm2Dgi
Serpina10tm1Gjb/Serpina10tm1Gjb 		involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:3804660
cx3
 		F5tm2Dgi/F5+
Serpina10tm1Gjb/Serpina10tm1Gjb 		involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:3804661


Genotype
MGI:3804658
hm1
Allelic
Composition		 Serpina10tm1Gjb/Serpina10tm1Gjb
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpina10tm1Gjb mutation (0 available); any Serpina10 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:136102 )
• mice show increased mortality in a collagen/epinephrine-induced thromboembolism model, with 67% of mice dying of respiratory arrest within 5 minutes of collagen/epinephrine administration compared to 27% in wild-type mice
decreased survivor rate ( J:136102 )
• analysis of 385 progeny of heterozygote parents reveals only 20% of mice are homozygotes at 6 weeks of age, which is significantly lower than the expected 25% incidence

homeostasis/metabolism
increased susceptibility to induced thrombosis ( J:136102 )
• ferric chloride-induced carotid artery injury leads to 60% occlusion after 40 minutes, which is significantly higher than the 28% occlusion that occurs in wild-type mice
• increased mortality from pulmonary thromboembolism following collagen/epinephrine infusion




Genotype
MGI:3804660
cx2
Allelic
Composition		 F5tm2Dgi/F5tm2Dgi
Serpina10tm1Gjb/Serpina10tm1Gjb
Genetic
Background		 involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F5tm2Dgi mutation (1 available); any F5 mutation (159 available)
Serpina10tm1Gjb mutation (0 available); any Serpina10 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:136102 )
• no mice survive until 6 weeks of age
• only 4% of embryos out of an expected 25% live until E18.5 with this genotype, which is significantly different from the normal number of E18.5 embryos found with a Proztm1Gjb / Proztm1Gjb F5tm2Dgi / F5tm2Dgi genotype
• normal numbers of double homozygotes are found at E13.5

cardiovascular system
hemoperitoneum ( J:136102 )
• is often observed in E13.5 embryos
intracranial hemorrhage ( J:136102 )
• is often observed in E13.5 embryos

nervous system
intracranial hemorrhage ( J:136102 )
• is often observed in E13.5 embryos




Genotype
MGI:3804661
cx3
Allelic
Composition		 F5tm2Dgi/F5+
Serpina10tm1Gjb/Serpina10tm1Gjb
Genetic
Background		 involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F5tm2Dgi mutation (1 available); any F5 mutation (159 available)
Serpina10tm1Gjb mutation (0 available); any Serpina10 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:136102 )
• only 18% of mice with this genotype are found at 6 weeks of age instead of the expected 25% based on Mendelian inheritance




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory