All Phenotypes Gsk3b<tm2Jrw> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gsk3b^tm2Jrw
targeted mutation 2, James R Woodgett
MGI:3794785

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Apc^tm1Tno/Apc^tm1Tno Gsk3a^tm1Jrw/Gsk3a^tm1Jrw Gsk3b^tm2Jrw/Gsk3b^tm2Jrw	involves: 129 * C57BL/6 * CBA	MGI:4943266
cn2	Gsk3b^tm2Jrw/Gsk3b^tm2Jrw Tg(Ggt1-cre)M3Egn/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL	MGI:5429170
cn3	Gsk3b^tm2Jrw/Gsk3b^tm2Jrw Irs2^tm1Mfw/Irs2^tm1Mfw Tg(Ins2-cre)23Herr/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J	MGI:3802546

Allelic Composition	Apc^tm1Tno/Apc^tm1Tno Gsk3a^tm1Jrw/Gsk3a^tm1Jrw Gsk3b^tm2Jrw/Gsk3b^tm2Jrw
Genetic Background	involves: 129 * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (154 available)
Gsk3a^tm1Jrw mutation (0 available); any Gsk3a mutation (18 available)
Gsk3b^tm2Jrw mutation (2 available); any Gsk3b mutation (111 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal urinary bladder urothelium morphology ( J:164579 )

• mice develop hyperplastic lesions in the bladder unlike wild-type mice

Allelic Composition	Gsk3b^tm2Jrw/Gsk3b^tm2Jrw Tg(Ggt1-cre)M3Egn/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3b^tm2Jrw mutation (2 available); any Gsk3b mutation (111 available)
Tg(Ggt1-cre)M3Egn mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:167190 )

N	• mutant kidneys are normal in terms of gross appearance, size, color, and glomerular and tubulointerstitial histology • kidney function, urine albumin excretion, and urine-concentrating ability remain normal

abnormal renal tubule morphology ( J:167190 )

• mice exhibit increased glycogen content in the renal cortical tubules, as shown by PAS staining and biochemical analysis

• EM revealed increased deposition of glycogen particles closely associated with tubules of smooth endoplasmic reticulum

abnormal proximal convoluted tubule morphology ( J:167190 )

• intense glycogen staining is primarily detected in the brush border of the renal tubules

homeostasis/metabolism

increased glycogen level ( J:167190 )

• mice exhibit increased glycogen accumulation in the renal cortical tubules

Allelic Composition	Gsk3b^tm2Jrw/Gsk3b^tm2Jrw Irs2^tm1Mfw/Irs2^tm1Mfw Tg(Ins2-cre)23Herr/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3b^tm2Jrw mutation (2 available); any Gsk3b mutation (111 available)
Irs2^tm1Mfw mutation (1 available); any Irs2 mutation (35 available)
Tg(Ins2-cre)23Herr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal circulating glucose level ( J:135659 )

• fed blood glucose concentration were significantly reduced relative to that in Irs2^tm1Mfw homozygous mice, though remained slightly higher than normal control

increased circulating insulin level ( J:135659 )

• both fasting and fed insulin levels were higher than in wild-type mice similar to the level found in Irs2^tm1Mfw homozygous mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23