All Phenotypes Tg(MMTV-Erbb2*)NDL2-5Mul MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(MMTV-Erbb2*)NDL2-5Mul
transgene insertion NDL2-5, William J Muller
MGI:3793949

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Erbb3^{tm1.1(ERBB3)Mul}/Erbb3^{tm1.1(ERBB3)Mul} Tg(MMTV-Erbb2*)NDL2-5Mul/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5447009
cx2	Erbb3^{tm1.1(ERBB3)Mul}/Erbb3⁺ Tg(MMTV-Erbb2*)NDL2-5Mul/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5447010
tg3	Tg(MMTV-Erbb2*)NDL2-5Mul/0	involves: C57BL/6	MGI:5447011

Allelic Composition	Erbb3^{tm1.1(ERBB3)Mul}/Erbb3^{tm1.1(ERBB3)Mul} Tg(MMTV-Erbb2*)NDL2-5Mul/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb3^{tm1.1(ERBB3)Mul} mutation (0 available); any Erbb3 mutation (47 available)
Tg(MMTV-Erbb2*)NDL2-5Mul mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:189292 )

decreased metastatic potential ( J:189292 )

• slight reduction in lung metastasis compared to in Tg(MMTV-Erbb2*)NDL2-5Mul mice

increased tumor latency ( J:189292 )

• compared to in Tg(MMTV-Erbb2*)NDL2-5Mul mice

integument

increased mammary gland tumor incidence ( J:189292 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:189292 )

Allelic Composition	Erbb3^{tm1.1(ERBB3)Mul}/Erbb3⁺ Tg(MMTV-Erbb2*)NDL2-5Mul/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:189292 )

increased tumor latency ( J:189292 )

• intermediate compared to in Tg(MMTV-Erbb2*)NDL2-5Mul mice

integument

increased mammary gland tumor incidence ( J:189292 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:189292 )

Allelic Composition	Tg(MMTV-Erbb2*)NDL2-5Mul/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:189292 )

integument

increased mammary gland tumor incidence ( J:189292 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:189292 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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