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Allele Symbol Allele Name Allele ID |
Pkd1tm2.1Som targeted mutation 2.1, Stefan Somlo MGI:3793792 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die between P14 and P17 of renal failure
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• at P7, proliferation of the cyst lining cells in the kidney is increased compared to in wild-type mice
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• mice exhibit a rapid progression of polycystic disease
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• an increased kidney weight to body weight ratio is observed at day 4 and increases rapidly thereafter
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• mice die between P14 and P17 of renal failure
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• the rapid increase in blood urea nitrogen level is associated with the cystic enlargement of the kidneys
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• at two weeks of age
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• at two weeks of age
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• mice exhibit a rapid progression of polycystic disease
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• an increased kidney weight to body weight ratio is observed at day 4 and increases rapidly thereafter
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| polycystic kidney disease 1 | DOID:0110858 |
OMIM:173900 |
J:135301 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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