All Phenotypes Plxna2<nmf454> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Plxna2^nmf454
neuroscience mutagenesis facility 454
MGI:3793765

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plxna2^nmf454/Plxna2^nmf454	involves: C57BL/6J	MGI:3795754

Allelic Composition	Plxna2^nmf454/Plxna2^nmf454
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna2^nmf454 mutation (1 available); any Plxna2 mutation (128 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased neuronal migration ( J:135408 )

• in migrating granule cells the average distance between the centrosome and nucleus is decreased

ectopic cerebellar granule cells ( J:135408 )

• many granule cells are present in the molecular layer

• hypercellular

behavior/neurological

ataxia ( J:135408 )

• subtle ataxic gait, not seen in all homozygotes

growth/size/body

decreased body size ( J:135408 )

cellular

decreased neuronal migration ( J:135408 )

• in migrating granule cells the average distance between the centrosome and nucleus is decreased

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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