All Phenotypes Gata6<tm3.1Sad> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gata6^tm3.1Sad
targeted mutation 3.1, Stephen A Duncan
MGI:3793425

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Gata4^tm1.2Sad/Gata4^tm1.2Sad Gata6^tm3.1Sad/Gata6^tm3.1Sad	involves: 129	MGI:3803459

Allelic Composition	Gata4^tm1.2Sad/Gata4^tm1.2Sad Gata6^tm3.1Sad/Gata6^tm3.1Sad
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4^tm1.2Sad mutation (0 available); any Gata4 mutation (36 available)
Gata6^tm3.1Sad mutation (0 available); any Gata6 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal cardiogenic mesoderm morphology ( J:135185 )

• failure to form the heart tube is specific to the development of the cardiogenic mesoderm without effects on gastrulation or mesodermal migration

abnormal fetal cardiomyocyte morphology ( J:135185 )

• differentiated cardiomyocytes are not found in E7.5 or E8.5 embryos

• cardiac myocytes in E8.5 embryos fail to express smooth muscle actin, alpha myosin heavy chain, and alpha cardiac actin

absent heart tube ( J:135185 )

• the heart tube fails to form in E8.5 embryos

absent heart ( J:135185 )

embryo

abnormal cardiogenic mesoderm morphology ( J:135185 )

• failure to form the heart tube is specific to the development of the cardiogenic mesoderm without effects on gastrulation or mesodermal migration

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