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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nat1Rgsc1523
RIKEN Genomic Sciences Center (GSC), 1523
MGI:3793317
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nat1Rgsc1523/Nat1Rgsc1523 involves: C57BL/6 * DBA/2 MGI:3807280
ht2
 		Nat1Rgsc1523/Nat1+ involves: C57BL/6 * DBA/2 MGI:3807281


Genotype
MGI:3807280
hm1
Allelic
Composition		 Nat1Rgsc1523/Nat1Rgsc1523
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nat1Rgsc1523 mutation (0 available); any Nat1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reduced fertility ( J:134504 )
• homozygous matings produced only 1 litter each for 2 breeding pairs

liver/biliary system
decreased liver enzyme/coenzyme activity ( J:134504 )
• hepatic N-acteyltransferase 1 activity is reduced by 90% compared to wild-type

homeostasis/metabolism
decreased liver enzyme/coenzyme activity ( J:134504 )
• hepatic N-acteyltransferase 1 activity is reduced by 90% compared to wild-type




Genotype
MGI:3807281
ht2
Allelic
Composition		 Nat1Rgsc1523/Nat1+
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nat1Rgsc1523 mutation (0 available); any Nat1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
decreased liver enzyme/coenzyme activity ( J:134504 )
• hepatic N-acteyltransferase 1 activity is reduced by >50% compared to wild-type

homeostasis/metabolism
decreased liver enzyme/coenzyme activity ( J:134504 )
• hepatic N-acteyltransferase 1 activity is reduced by >50% compared to wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory