All Phenotypes Nr1i2<tm1(NR1I2)Arte> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nr1i2^{tm1(NR1I2)Arte}
targeted mutation 1, TaconicArtemis
MGI:3790844

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr1i2^{tm1(NR1I2)Arte}/Nr1i2^{tm1(NR1I2)Arte}	involves: C57BL/6	MGI:3815122
cx2	Abcc2^{tm1.1(ABCC2)Arte}/Abcc2^{tm1.1(ABCC2)Arte} Nr1i2^{tm1(NR1I2)Arte}/Nr1i2^{tm1(NR1I2)Arte}	involves: C57BL/6	MGI:5609259
cx3	Nr1i2^{tm1(NR1I2)Arte}/Nr1i2^{tm1(NR1I2)Arte} Nr1i3^tm1.1Arte/Nr1i3^tm1.1Arte	involves: C57BL/6NTac	MGI:3815127

Allelic Composition	Nr1i2^{tm1(NR1I2)Arte}/Nr1i2^{tm1(NR1I2)Arte}
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1i2^{tm1(NR1I2)Arte} mutation (2 available); any Nr1i2 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:140975 )

N	• mice exhibit normal survival

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:140975 )

• mice exhibit decreased induction of Cyp3a11 expression following treatment with dexamethasone or clotrimazole than in similarly treated wild-type mice

• however, mice exhibit normal induction of Cyp2b10 expression following treatment with dexamethasone

increased physiological sensitivity to xenobiotic ( J:140975 )

• mice exhibit increased induction of Cyp3a11 expression at lower doses of RIF than in similarly treated wild-type mice

• however, mice do not exhibit induction of Cyp2b10 expression following treatment with RIF

liver/biliary system

liver/biliary system phenotype ( J:140975 )

N	• mice exhibit normal liver histology

reproductive system

reproductive system phenotype ( J:140975 )

N	• mice exhibit normal fertility

Allelic Composition	Abcc2^{tm1.1(ABCC2)Arte}/Abcc2^{tm1.1(ABCC2)Arte} Nr1i2^{tm1(NR1I2)Arte}/Nr1i2^{tm1(NR1I2)Arte}
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc2^{tm1.1(ABCC2)Arte} mutation (0 available); any Abcc2 mutation (90 available)
Nr1i2^{tm1(NR1I2)Arte} mutation (2 available); any Nr1i2 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:216646 )

N	• plasma and urine bilirubin levels are similar to controls

Allelic Composition	Nr1i2^{tm1(NR1I2)Arte}/Nr1i2^{tm1(NR1I2)Arte} Nr1i3^tm1.1Arte/Nr1i3^tm1.1Arte
Genetic Background	involves: C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1i2^{tm1(NR1I2)Arte} mutation (2 available); any Nr1i2 mutation (33 available)
Nr1i3^tm1.1Arte mutation (4 available); any Nr1i3 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:140975 )

• mice fail to exhibit phenobarbital induced Cyp3a11 or Cyp2b10 expression

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