Phenotypes associated with this allele

• Allele Symbol: Igh^tm12Cgn
• Allele Name: targeted mutation 12, University of Cologne
• Allele ID: MGI:3790800
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh^tm12Cgn/Igh^tm12Cgn	involves: 129P2/OlaHsd	MGI:3790801

Genotype
MGI:3790801

hm1

• Allelic Composition: Igh^tm12Cgn/Igh^tm12Cgn
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal somatic hypermutation frequency ( J:66031 )

• the frequency of deletions that occur in the IgH locus during the course of somatic hypermutation is similar to wild-type but the size of the deletions is significantly larger with 80% of the deletions being over a 100bp while deletions in control mice range in size from 3-32 bp

• deletions occur at characteristic RGYW motifs

hematopoietic system

abnormal somatic hypermutation frequency ( J:66031 )

• the frequency of deletions that occur in the IgH locus during the course of somatic hypermutation is similar to wild-type but the size of the deletions is significantly larger with 80% of the deletions being over a 100bp while deletions in control mice range in size from 3-32 bp

• deletions occur at characteristic RGYW motifs