Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(CAG-Foxo1*)Jcbr}
• Allele Name: targeted mutation 1, Jens C Bruning
• Allele ID: MGI:3790725
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(CAG-Foxo1*)Jcbr/Gt(ROSA)26Sor^+ Pdpk1^tm1Jcbr/Pdpk1^tm1Jcbr Tg(Pomc1-cre)16Lowl/0	involves: C57BL/6 * FVB/N	MGI:3804312

Genotype
MGI:3804312

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Foxo1*)Jcbr}/Gt(ROSA)26Sor⁺; Pdpk1^tm1Jcbr/Pdpk1^tm1Jcbr; Tg(Pomc1-cre)16Lowl/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:134336 )

N • expression of the mutant foxo1 restores body weight, food consumption and blood glucose levels to normal

decreased circulating corticosterone level ( J:134336 )

• mutants have reduced basal and stress-induced corticosterone levels, similar to double Pdk1^tm1Jcbr Tg(Pomc1-cre)16Lowl mutants

endocrine/exocrine glands

decreased corticotroph cell number ( J:134336 )

• same reduction in corticotrophs as seen in double Pdk1^tm1Jcbr Tg(Pomc1-cre)16Lowl mutants

nervous system

decreased corticotroph cell number ( J:134336 )

• same reduction in corticotrophs as seen in double Pdk1^tm1Jcbr Tg(Pomc1-cre)16Lowl mutants