Phenotypes associated with this allele

• Allele Symbol: Hrg^tm1Wja
• Allele Name: targeted mutation 1, Willi Jahnen-Dechent
• Allele ID: MGI:3789962
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hrg^tm1Wja/Hrg^tm1Wja	involves: 129P2/OlaHsd * C57BL/6	MGI:3789963

Genotype
MGI:3789963

hm1

• Allelic Composition: Hrg^tm1Wja/Hrg^tm1Wja
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased monocyte cell number ( J:134621 )

• mild

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:134621 )

N • despite abnormalities in coagulation and fibrinolysis no significant differences are detected in skin wound healing

increased circulating fibrinogen level ( J:134621 )

• 35% increase in plasma fibrinogen levels in females compared to wild-type controls

abnormal thrombolysis ( J:134621 )

• faster spontaneous clot lysis

decreased bleeding time ( J:134621 )

• in a tail bleed assay

decreased prothrombin time ( J:134621 )

• significant reduction in prothrombin time compared to wild-type controls

immune system

increased monocyte cell number ( J:134621 )

• mild

increased circulating fibrinogen level ( J:134621 )

• 35% increase in plasma fibrinogen levels in females compared to wild-type controls