Phenotypes associated with this allele

• Allele Symbol: Tg(Myod1-BCL2)1Jbm
• Allele Name: transgene insertion 1, Jeffrey Boone Miller
• Allele ID: MGI:3789480
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Lama2^tm1Eeng/Lama2^tm1Eeng Tg(Myod1-BCL2)1Jbm/?	B6.Cg-Lama2^tm1Eeng Tg(Myod1-BCL2)1Jbm	MGI:3789481

Genotype
MGI:3789481

cx1

• Allelic Composition: Lama2^tm1Eeng/Lama2^tm1Eeng; Tg(Myod1-BCL2)1Jbm/?
• Genetic Background: B6.Cg-Lama2^tm1Eeng Tg(Myod1-BCL2)1Jbm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

extended life span ( J:94431 )

• early death found in Lama2 homozygotes is prevented by this transgenic restricted expression of human BCL2 in skeletal muscle, survival exceeds 90 days in all of 6 mice and half lived longer than 120 days

growth/size/body

abnormal postnatal growth/weight/body size ( J:94431 )

• transgenic expression of BCL2 results in increased weight gain and growth rate relative to non-transgenic Lama2 mutants, but does not entirely rescue Lama2 mutants from diminished weight gain and growth