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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm4(RNAi:Gsk3a,Gsk3b)Rkuhn
targeted mutation 4, Ralf Kuhn
MGI:3785819
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Gt(ROSA)26Sortm4(RNAi:Gsk3a,Gsk3b)Rkuhn/Gt(ROSA)26Sor+ involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:3785846


Genotype
MGI:3785846
ht1
Allelic
Composition		 Gt(ROSA)26Sortm4(RNAi:Gsk3a,Gsk3b)Rkuhn/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(RNAi:Gsk3a,Gsk3b)Rkuhn mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:133340 )
• mice have a strong reduction in body weight compared to littermate controls

reproductive system
transmission ratio distortion ( J:133340 )
• mice are obtained at half (12.5%) of the expected (25%) frequency




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory