All Phenotypes Ppp1r3a<tm2Adpr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ppp1r3a^tm2Adpr
targeted mutation 2, Anna A DePaoli-Roach
MGI:3785748

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppp1r3a^tm2Adpr/Ppp1r3a^tm2Adpr	involves: 129S6/SvEvTac * C57BL/6J	MGI:3789680
ht2	Ppp1r3a^tm2Adpr/Ppp1r3a⁺	involves: 129S6/SvEvTac * C57BL/6J	MGI:3789681

Allelic Composition	Ppp1r3a^tm2Adpr/Ppp1r3a^tm2Adpr
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r3a^tm2Adpr mutation (0 available); any Ppp1r3a mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal glycogen homeostasis ( J:134157 )

• 68% reduction in glycogen synthase to glucose-6-phosphate ratio reflecting a reduction in phosphorylation and activity of glycogen synthase

• however, whole body glycogen synthesis and glycolysis, muscle specific insulin-stimulated glycogen synthesis and glucose and insulin tolerances are all similar to controls

decreased skeletal muscle glycogen level ( J:134157 )

• 55% reduction in skeletal muscle glycogen content compared to wild-type controls

muscle

decreased skeletal muscle glycogen level ( J:134157 )

• 55% reduction in skeletal muscle glycogen content compared to wild-type controls

Allelic Composition	Ppp1r3a^tm2Adpr/Ppp1r3a⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r3a^tm2Adpr mutation (0 available); any Ppp1r3a mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal glycogen homeostasis ( J:134157 )

• 45% reduction in glycogen synthase to glucose-6-phosphate ratio reflecting a reduction in phosphorylation and activity of glycogen synthase

• however, whole body glycogen synthesis and glycolysis, muscle specific insulin-stimulated glycogen synthesis and glucose and insulin tolerances are all similar to controls

decreased skeletal muscle glycogen level ( J:134157 )

• 40% reduction in skeletal muscle glycogen content compared to wild-type controls

muscle

decreased skeletal muscle glycogen level ( J:134157 )

• 40% reduction in skeletal muscle glycogen content compared to wild-type controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23