About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ltb4r2tm1Tksh
targeted mutation 1, Takao Schimizu
MGI:3785609
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ltb4r2tm1Tksh/Ltb4r2tm1Tksh B6.Cg-Ltb4r2tm1Tksh MGI:5517588
hm2
 		Ltb4r2tm1Tksh/Ltb4r2tm1Tksh C.Cg-Ltb4r2tm1Tksh MGI:5517541


Genotype
MGI:5517588
hm1
Allelic
Composition		 Ltb4r2tm1Tksh/Ltb4r2tm1Tksh
Genetic
Background		 B6.Cg-Ltb4r2tm1Tksh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb4r2tm1Tksh mutation (2 available); any Ltb4r2 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to type I hypersensitivity reaction ( J:197334 )
• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit decreased dye extravasation (a measure of edema) compared with wild-type mice

homeostasis/metabolism
edema ( J:197334 )
• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit decreased dye extravasation (a measure of edema) compared with wild-type mice




Genotype
MGI:5517541
hm2
Allelic
Composition		 Ltb4r2tm1Tksh/Ltb4r2tm1Tksh
Genetic
Background		 C.Cg-Ltb4r2tm1Tksh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb4r2tm1Tksh mutation (2 available); any Ltb4r2 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:133998 )
• bone marrow-derived mast cells fail to migrate in response to 12-12(S)-hydroxyheptadeca-5Z, 8E, 10E-trienoic acid (12-HHT) unlike wild-type cells
• however, bone marrow-derived mast cells exhibit normal migration in response to LTB4 and stem cell factor (SCF)

hematopoietic system
abnormal mast cell physiology ( J:133998 )
• bone marrow-derived mast cells fail to migrate in response to 12-12(S)-hydroxyheptadeca-5Z, 8E, 10E-trienoic acid (12-HHT) unlike wild-type cells
• however, bone marrow-derived mast cells exhibit normal migration in response to LTB4 and stem cell factor (SCF)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory