Phenotypes associated with this allele

• Allele Symbol: Gad1^{tm1(Gria2)Mony}
• Allele Name: targeted mutation 1, Hannah Monyer
• Allele ID: MGI:3785546
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gad1^tm1(Gria2)Mony/Gad1^tm1(Gria2)Mony	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3796154

Genotype
MGI:3796154

hm1

• Allelic Composition: Gad1^{tm1(Gria2)Mony}/Gad1^{tm1(Gria2)Mony}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain wave pattern ( J:134013 )

• gamma-frequency neuronal oscillations that normally synchronize within milliseconds of two site stimulation of the hippocampus fail to synchronize in mutant mice

abnormal excitatory postsynaptic potential ( J:134013 )

• a significantly larger number of longer slower-to-peak EPSPs are seen in mutant stratum pyramidale interneurons

• single shock stimulation at 5-20 V elicits EPSPs with spike doublets at intensities more than 10 V compared to the singlet spikes in wild-type mice

• two site stimulated gamma oscillation elicits doublet and triplet EPSPs while only eliciting singlets and doublets in wild-type mice