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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gpx4tm1Ssd
targeted mutation 1, Samir S Deeb
MGI:3785543
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gpx4tm1Ssd/Gpx4tm1Ssd B6.129-Gpx4tm1Ssd MGI:3796140
ht2
 		Gpx4tm1Ssd/Gpx4+ B6.129-Gpx4tm1Ssd MGI:3796141


Genotype
MGI:3796140
hm1
Allelic
Composition		 Gpx4tm1Ssd/Gpx4tm1Ssd
Genetic
Background		 B6.129-Gpx4tm1Ssd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx4tm1Ssd mutation (0 available); any Gpx4 mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:134214 )
• do not survive development past E10.5




Genotype
MGI:3796141
ht2
Allelic
Composition		 Gpx4tm1Ssd/Gpx4+
Genetic
Background		 B6.129-Gpx4tm1Ssd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx4tm1Ssd mutation (0 available); any Gpx4 mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitochondrial physiology ( J:134214 )
• lung fibroblasts have a lower mitochondrial membrane potential, lower levels of reduced thiols, and lower overall levels of cardiolipins
• thiol and cardiolipin oxidation that results from chemical agents causing oxidative stress is reduced in mitochondria of lung fibroblasts
oxidative stress ( J:134214 )
• fibroblasts from lung have increased cytotoxicity to chemicals that cause oxidative stress including low doses of hydrogen peroxide (25 micromolar) and cadmium (concentrations between 75 and 200 micromolar)
• however, fibroblasts have decreased cytotoxicity to phosphatidylcholine hydroperoxide




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory