Phenotypes associated with this allele

• Allele Symbol: Tg(ARR2/Pbsn-MYC)7Key
• Allele Name: transgene insertion 7, Katharine Ellwood-Yen
• Allele ID: MGI:3785495
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Mirc1^tm2.1Aven/Mirc1^tm2.1Aven Tg(ARR2/Pbsn-MYC)7Key/0	involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL/J	MGI:5662416
tg2	Tg(ARR2/Pbsn-MYC)7Key/?	involves: FVB/N	MGI:5486199

Genotype
MGI:5662416

cx1

• Allelic Composition: Mirc1^tm2.1Aven/Mirc1^tm2.1Aven; Tg(ARR2/Pbsn-MYC)7Key/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

small prostate gland ( J:223213 )

• prostate volume is reduced compared to Tg(ARR2/Pbsn-MYC)7Key alone

decreased prostate gland tumor incidence ( J:223213 )

• prostrates from 8 week old males exhibit occasional prostatic intraepithelial neoplasia in contrast to Tg(ARR2/Pbsn-MYC)7Key alone

increased prostate gland adenocarcinoma incidence ( J:223213 )

• invasive prostatic adenocarcinoma is not observed until 14 months of age in contrast to Tg(ARR2/Pbsn-MYC)7Key alone

reproductive system

small prostate gland ( J:223213 )

• prostate volume is reduced compared to Tg(ARR2/Pbsn-MYC)7Key alone

increased prostate gland adenocarcinoma incidence ( J:223213 )

• invasive prostatic adenocarcinoma is not observed until 14 months of age in contrast to Tg(ARR2/Pbsn-MYC)7Key alone

neoplasm

decreased prostate gland tumor incidence ( J:223213 )

• prostrates from 8 week old males exhibit occasional prostatic intraepithelial neoplasia in contrast to Tg(ARR2/Pbsn-MYC)7Key alone

increased prostate gland adenocarcinoma incidence ( J:223213 )

• invasive prostatic adenocarcinoma is not observed until 14 months of age in contrast to Tg(ARR2/Pbsn-MYC)7Key alone

Genotype
MGI:5486199

tg2

• Allelic Composition: Tg(ARR2/Pbsn-MYC)7Key/?
• Genetic Background: involves: FVB/N

neoplasm

increased prostate gland tumor incidence ( J:85480 )

♂ • transition to cancer occurs in all male mice by 3-6 months of age and to invasive adenocarcinoma of the prostate after 6 months of age

♂ • mice castrated at 8 months of age (when all have prostate cancer) show evidence of regression and fibrosis at all time points post-castration and the presence of residual tumors that do not express the MYC transgene

increased prostate gland adenocarcinoma incidence ( J:85480 , J:223213 )

♂ • invasive carcinoma of the prostate after 6 months of age (J:85480)

♂ • males develop invasive prostatic adenocarcinomas by 8 months of age (J:223213)

increased prostate intraepithelial neoplasia incidence ( J:85480 , J:223213 )

♂ • all male mice develop prostatic intraepithelial neoplasia (mPIN) by 3 months of age; lesions can be seen as early as 2 weeks of age (J:85480)

♂ • mice castrated at 2 months of age (when mPIN lesions are present) exhibit complete regression of mPIN within one month of castration (J:85480)

♂ • prostrates from 8 week old mice exhibit extensive prostatic intraepithelial neoplasia as compared to controls (J:223213)

endocrine/exocrine glands

enlarged prostate gland ( J:223213 )

♂ • prostrate volume is increased as compared to controls

increased prostate gland tumor incidence ( J:85480 )

♂ • transition to cancer occurs in all male mice by 3-6 months of age and to invasive adenocarcinoma of the prostate after 6 months of age

♂ • mice castrated at 8 months of age (when all have prostate cancer) show evidence of regression and fibrosis at all time points post-castration and the presence of residual tumors that do not express the MYC transgene

increased prostate gland adenocarcinoma incidence ( J:85480 , J:223213 )

♂ • invasive carcinoma of the prostate after 6 months of age (J:85480)

♂ • males develop invasive prostatic adenocarcinomas by 8 months of age (J:223213)

increased prostate intraepithelial neoplasia incidence ( J:85480 , J:223213 )

♂ • all male mice develop prostatic intraepithelial neoplasia (mPIN) by 3 months of age; lesions can be seen as early as 2 weeks of age (J:85480)

♂ • mice castrated at 2 months of age (when mPIN lesions are present) exhibit complete regression of mPIN within one month of castration (J:85480)

♂ • prostrates from 8 week old mice exhibit extensive prostatic intraepithelial neoplasia as compared to controls (J:223213)

reproductive system

enlarged prostate gland ( J:223213 )

♂ • prostrate volume is increased as compared to controls

increased prostate gland tumor incidence ( J:85480 )

♂ • transition to cancer occurs in all male mice by 3-6 months of age and to invasive adenocarcinoma of the prostate after 6 months of age

♂ • mice castrated at 8 months of age (when all have prostate cancer) show evidence of regression and fibrosis at all time points post-castration and the presence of residual tumors that do not express the MYC transgene

increased prostate gland adenocarcinoma incidence ( J:85480 , J:223213 )

♂ • invasive carcinoma of the prostate after 6 months of age (J:85480)

♂ • males develop invasive prostatic adenocarcinomas by 8 months of age (J:223213)

increased prostate intraepithelial neoplasia incidence ( J:85480 , J:223213 )

♂ • all male mice develop prostatic intraepithelial neoplasia (mPIN) by 3 months of age; lesions can be seen as early as 2 weeks of age (J:85480)

♂ • mice castrated at 2 months of age (when mPIN lesions are present) exhibit complete regression of mPIN within one month of castration (J:85480)

♂ • prostrates from 8 week old mice exhibit extensive prostatic intraepithelial neoplasia as compared to controls (J:223213)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:85480