All Phenotypes Trim55<tm1Cpat> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim55^tm1Cpat/Trim55^tm1Cpat	involves: 129 * C57BL/6	MGI:3785745
cx2	Trim55^tm1Cpat/Trim55^tm1Cpat Trim63^tm1Glas/Trim63^tm1Glas	involves: 129S1/Sv * C57BL/6	MGI:6258325
cx3	Trim55^tm1Cpat/Trim55^tm1Cpat Trim63^tm1Glas/Trim63⁺	involves: 129S1/Sv * C57BL/6	MGI:6258326
cx4	Trim55^tm1Cpat/Trim55⁺ Trim63^tm1Glas/Trim63^tm1Glas	involves: 129S1/Sv * C57BL/6	MGI:6258327

Allelic Composition	Trim55^tm1Cpat/Trim55^tm1Cpat
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim55^tm1Cpat mutation (0 available); any Trim55 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:133708 )

N	• despite a predicted role in titin dynamics, no structural or functional abnormalities are seen in the heart and hypertrophic responses to transaortic constriction are similar to those in wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:267246 )

• 4 of 11 mice that survive to adulthood die between 0.7 to 3.3 months of age

postnatal lethality, incomplete penetrance ( J:267246 )

• of the mice that are born alive, 19 of 25 die between birth and P23, with an average death at P14, while the remaining 6 survive to adulthood

prenatal lethality, incomplete penetrance ( J:267246 )

• significant decrease in the expected number of pups of born, with approximately 67.1% of mutants dying in utero

growth/size/body

cardiac hypertrophy ( J:267246 )

• mice that die in utero show extensive cardiac hypertrophy, with the majority of thoracic cavity taken up by the enlarged heart

• mice surviving birth develop cardiac hypertrophy showing increased heart weight/tibia length, increased gross histological size, and increased cardiomyocyte cross sectional area

cardiovascular system

abnormal myocardial fiber morphology ( J:267246 )

• hearts of mice that die on average at P14 show gross mitochondria abnormalities

cardiac hypertrophy ( J:267246 )

• mice that die in utero show extensive cardiac hypertrophy, with the majority of thoracic cavity taken up by the enlarged heart

• mice surviving birth develop cardiac hypertrophy showing increased heart weight/tibia length, increased gross histological size, and increased cardiomyocyte cross sectional area

cardiac fibrosis ( J:267246 )

• mice that die in utero show presence of cardiac fibrosis

• mice that die within the first several weeks of life show widespread cardiac fibrosis

• however, mice that survive to adulthood do not exhibit cardiac fibrosis

decreased cardiac muscle contractility ( J:267246 )

• mice that survive to adulthood show defects in cardiac function, including decreased fractional shortening and ejection fraction at 6 weeks of age, and a dramatic decrease in the percentage of fractional shortening at 12 weeks of age

abnormal heart echocardiography feature ( J:267246 )

• echocardiography at 12 weeks of age shows increased left ventricular mass index and mass, increased interventricular septal thickness in systole, increased posterior wall thickness in diastole, decreased posterior wall thickness in systole, increased left ventricular end-diastolic dimension and left ventricular end-systolic dimension and reduced percent ejection fraction

congestive heart failure ( J:267246 )

• cause of death in mice that die in the first 2 weeks of life appears to be heart failure, as indicated by a decrease in cardiac function and edematous lungs

homeostasis/metabolism

pulmonary edema ( J:267246 )

• mice that die within the first 2 weeks of life exhibit edematous lungs

muscle

abnormal myocardial fiber morphology ( J:267246 )

• hearts of mice that die on average at P14 show gross mitochondria abnormalities

decreased cardiac muscle contractility ( J:267246 )

abnormal sarcomere morphology ( J:267246 )

• hearts from mice that die on average at P14 exhibit disrupted sarcomeres, with both Z disc and M line defects

• however, no sarcomere defects are seen in skeletal muscle

abnormal M line morphology ( J:267246 )

• hearts of mice that die on average at P14 show M line defects

abnormal Z line morphology ( J:267246 )

• hearts of mice that die on average at P14 show Z disc defects

respiratory system

pulmonary edema ( J:267246 )

• mice that die within the first 2 weeks of life exhibit edematous lungs

Allelic Composition	Trim55^tm1Cpat/Trim55^tm1Cpat Trim63^tm1Glas/Trim63⁺
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim55^tm1Cpat mutation (0 available); any Trim55 mutation (33 available)
Trim63^tm1Glas mutation (0 available); any Trim63 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:267246 )

N	• mice exhibit a normal cardiac phenotype and no deficit in fractional shortening

Allelic Composition	Trim55^tm1Cpat/Trim55⁺ Trim63^tm1Glas/Trim63^tm1Glas
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:267246 )

N	• mice exhibit a normal cardiac phenotype and no deficit in fractional shortening

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