Phenotypes associated with this allele

• Allele Symbol: Stat1^m2Btlr
• Allele Name: mutation 2, Bruce Beutler
• Allele ID: MGI:3785244
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stat1^m2Btlr/Stat1^m2Btlr	C57BL/6J-Stat1^m2Btlr	MGI:3785246

Genotype
MGI:3785246

hm1

• Allelic Composition: Stat1^m2Btlr/Stat1^m2Btlr
• Genetic Background: C57BL/6J-Stat1^m2Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased NK cell degranulation ( J:134096 )

• homozygous mutant NK cells fail to degranulate following exposure to YAC-1 tumor cells

• NK cells from homozygous mutants degranulate normally following stimulation with antibodies against Ly49D, NK1.1 or NKp46 receptors or after exposure to interleukin (IL)-12, IL-2 or IL-18

impaired natural killer cell mediated cytotoxicity ( J:134096 )

• homozygous mutants injected with fluorescently labeled splenocytes exhibit diminished ability to kill TAP-deficient target cells lacking MHC class I molecules

• homozygotes injected with fluorescent splenocytes from C3H/HeN, bearing allogeneic MHC molecules, exhibit normal ability to kill the target cells

decreased interferon-gamma secretion ( J:134096 )

• homozygous mutant NK cells fail to produce interferon gamma (IFN-gamma) following exposure to YAC-1 tumor cells

• NK cells from homozygous mutants produce normal amounts of interferon (IFN)-gamma following stimulation with antibodies against Ly49D, NK1.1 or NKp46 receptors or after exposure to interleukin (IL)-12, IL-2 or IL-18.

increased susceptibility to Herpesvirales infection ( J:134096 )

• mice homozygous for this mutation have increased susceptibility to infection by mouse cytomegalovirus (MCMV); 100% of mice succumb by day 5 post-infection with 105 pfu of MCMV, a normally sublethal inoculum

hematopoietic system

decreased NK cell degranulation ( J:134096 )

• homozygous mutant NK cells fail to degranulate following exposure to YAC-1 tumor cells

• NK cells from homozygous mutants degranulate normally following stimulation with antibodies against Ly49D, NK1.1 or NKp46 receptors or after exposure to interleukin (IL)-12, IL-2 or IL-18

impaired natural killer cell mediated cytotoxicity ( J:134096 )

• homozygous mutants injected with fluorescently labeled splenocytes exhibit diminished ability to kill TAP-deficient target cells lacking MHC class I molecules

• homozygotes injected with fluorescent splenocytes from C3H/HeN, bearing allogeneic MHC molecules, exhibit normal ability to kill the target cells

cellular

decreased NK cell degranulation ( J:134096 )

• homozygous mutant NK cells fail to degranulate following exposure to YAC-1 tumor cells

• NK cells from homozygous mutants degranulate normally following stimulation with antibodies against Ly49D, NK1.1 or NKp46 receptors or after exposure to interleukin (IL)-12, IL-2 or IL-18